Indications
Adora treats bacterial infections including:

• Streptococcal pharyngitis/tonsillitis

• Bronchopneumonia and bacterial pneumonia

• Uncomplicated urinary tract infections (pyelonephritis, cystitis)

• Skin/soft tissue infections (abscesses, furunculosis, impetigo, erysipelas, pyoderma, lymphadenitis)
  রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Pharmacology
Cefadroxil inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan assembly and causing cell death.

Dosage & Administration
Streptococcal Infections:

• Adults/Adolescents (>40 kg): 1000 mg once daily ≥10 days

• Children (<40 kg): 30 mg/kg/day once daily ≥10 days

Other Infections:

• Adults/Adolescents (>40 kg): 1000 mg twice daily

• Children (<40 kg): 30–35 mg/kg/day in divided doses
  *Max: 4 g/day; 500 mg tablets not recommended <6 years*

Renal Impairment:

• CrCl 50–25 ml/min: 500–1000 mg every 12 hr

• CrCl 25–10 ml/min: 500–1000 mg every 24 hr

• CrCl 10–0 ml/min: 500–1000 mg every 36 hr
  Not indicated for children with renal insufficiency

Hemodialysis: Additional 500–1000 mg post-dialysis
*Take with/without food; duration: Continue 2–3 days after symptom resolution*
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Interaction

• Prolongs prothrombin time with anticoagulants (bleeding risk)

• Probenecid reduces elimination

Contraindications
Hypersensitivity to cephalosporins, severe penicillin/beta-lactam reactions. Avoid with bacteriostatic antibiotics, aminoglycosides, or nephrotoxic agents.

Side Effects

• Common: Nausea, diarrhea, rash, abdominal pain

• Serious: Pseudomembranous colitis, anaphylaxis, Stevens-Johnson syndrome

• Hematologic: Eosinophilia, thrombocytopenia, hemolytic anemia

• Renal: Interstitial nephritis

Pregnancy & Lactation
Limited safety data; low concentrations in breast milk. Use strictly under medical supervision.

Precautions & Warnings

• Monitor blood counts, renal/hepatic function during prolonged use

• Discontinue if allergic reactions or severe diarrhea occur

• Use cautiously in penicillin-allergic patients, renal impairment, or colitis history

Overdose Effects
Possible nausea, hallucinations, renal impairment, or neurological symptoms (hyperreflexia, coma).

Therapeutic Class
First-generation cephalosporin

Storage Conditions
Store in dry, cool place protected from light. Keep away from children.