Indications
Amilin treats depressive illness (particularly with sedation needs), nocturnal enuresis in children, migraine prophylaxis, tension headaches, and chronic pain.
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Pharmacology
Amitriptyline (tricyclic antidepressant) blocks norepinephrine/serotonin reuptake, increasing synaptic concentrations. Its anticholinergic and sedative effects contribute to therapeutic actions. Rapidly absorbed; peak plasma levels in 2–12 hours. Excreted renally as metabolites.

Dosage & Administration

• Depression:

  • Adults: Start 75 mg/day (single bedtime or divided doses). Increase gradually to 150–200 mg/day.

  • Elderly/Adolescents: 30–75 mg/day initially.

  • Children <16 yrs: Not recommended.

• Nocturnal Enuresis:

  • 7–10 yrs: 10–20 mg at bedtime

  • 11–16 yrs: 25–50 mg at bedtime
    Max 3 months per course

• Migraine Prophylaxis: 100 mg daily

• Tension Headache: 10–25 mg three times daily
  রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Interaction

• Potentiates sedation: Alcohol, opioids

• Arrhythmia risk: Moxifloxacin, terfenadine

• Metabolism inhibitors: Disulfiram, cimetidine

• Hypotension risk: Diuretics

Contraindications
Recent MI, heart block, mania, severe liver disease, arrhythmias. Avoid driving initially due to sedation.

Side Effects

• Anticholinergic: Dry mouth, blurred vision, urinary retention

• Cardiovascular: Hypotension, tachycardia

• CNS: Confusion, delusions

• Allergic: Rash, photosensitivity

• GI: Nausea, constipation

• Hematologic: Bone marrow suppression

Pregnancy & Lactation
Category C: Use only if maternal benefit outweighs fetal risk. Excreted in breast milk; discontinue nursing.

Precautions & Warnings
Caution in epilepsy, glaucoma, cardiac disease, diabetes, hepatic/thyroid impairment, or psychosis (may trigger mania).

Therapeutic Class
Tricyclic antidepressant

Storage Conditions
Store below 30°C in dry, dark place. Protect from moisture.