Indications
Anclog reduces myocardial infarction and stroke risk in:

• Acute coronary syndrome (NSTEMI/unstable angina or STEMI)

• Recent MI/stroke

• Established peripheral arterial disease
  রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Pharmacology
Clopidogrel (prodrug) irreversibly binds to platelet P2Y₁₂ ADP receptors via active metabolites, inhibiting aggregation. Onset: 2 hours post-dose (loading dose). Steady-state inhibition achieved within 3–7 days at 75 mg daily.

Dosage & Administration

• Acute Coronary Syndrome: 300 mg loading dose, then 75 mg once daily

• Recent MI/Stroke/PAD: 75 mg once daily (no loading dose)
  Take with/without food.
  রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Interaction

• Bleeding risk ↑: NSAIDs, warfarin, SSRIs/SNRIs

• Avoid: Omeprazole/esomeprazole (CYP2C19 inhibitors), repaglinide

• Caution: Other CYP2C19 inhibitors (e.g., fluconazole)

Contraindications
Hypersensitivity, active bleeding (e.g., peptic ulcer, intracranial hemorrhage).

Side Effects

• Common: Bleeding, diarrhea, rash

• Rare: TTP, angioedema, acquired hemophilia, bone marrow disorders

Pregnancy & Lactation
Use only if benefits outweigh risks. Excretion in breast milk unknown; discontinue nursing.

Precautions & Warnings

• Genetic/drug interactions: Reduced efficacy in CYP2C19 poor metabolizers or with CYP2C19 inhibitors

• Bleeding risk: Persists 7–10 days after discontinuation

• Surgery: Stop 5 days pre-op; resume post-hemostasis

• TTP: Requires urgent plasmapheresis if occurs

• Hypersensitivity: Monitor if thienopyridine allergy history

Overdose Effects
Bleeding complications. Manage with platelet transfusion.

Therapeutic Class
P2Y₁₂ platelet inhibitor

Storage Conditions
Store below 30°C in dry, dark place. Do not freeze. Keep from children.