Angilock® (Losartan Potassium) - Professional Product Information

Indications

1. Hypertension

   • Monotherapy or combination with other antihypertensives (e.g., thiazide diuretics).

2. Renoprotection in Type 2 Diabetes

   • Delays progression of renal disease in hypertensive patients with proteinuria (UACR >300 mg/g). 
     (Use under registered physician's guidance)

Pharmacology

• Mechanism: Selective, non-peptide angiotensin II receptor blocker (ARB). Binds reversibly to AT₁ receptors in vascular smooth muscle, adrenal glands, kidneys, and heart.

• Key Actions:

  • Inhibits angiotensin II-induced vasoconstriction and aldosterone release.

  • Reduces blood pressure and glomerular pressure (renal protective effect).

Dosage & Administration

Standard Dosing

*Volume depletion: High-dose diuretic therapy, dehydration. 
Dose adjustment interval: 2–4 weeks.

Administration

• May be taken once or twice daily (split doses if >50 mg/day).

• No food restrictions. 
  (Follow registered physician's advice)

Interactions

Contraindications

• Pregnancy (all trimesters)

• Hypersensitivity to losartan

• Concomitant aliskiren in diabetics

• Bilateral renal artery stenosis

Side Effects

Common (>5%):

• Dizziness • Upper respiratory infection • Headache

• Mild diarrhea • Nasal congestion

Less Common:

• Fatigue • Edema • Hyperkalemia • Transient renal impairment

Pregnancy & Lactation

• Pregnancy (Category D):

  • Fetal renal damage/neonatal death risk (2nd/3rd trimesters). Discontinue immediately if pregnancy detected.

• Lactation: Avoid nursing (excretion unknown; potential infant risk).

Precautions & Warnings

1. Renal Impairment:

   • Mild (CrCl 20–50 mL/min): No initial adjustment.

   • Moderate-severe (CrCl <20 mL/dialysis): Start at 25 mg/day.

2. Hepatic Impairment:

   • Cirrhosis: Start at 25 mg/day (↑ bioavailability).

3. Volume Depletion: Risk of symptomatic hypotension.

4. Hyperkalemia: Monitor serum K⁺ (especially with CKD/diabetes).

5. Surgery/Anesthesia: Discontinue 24h pre-procedure (hypotension risk).

Therapeutic Class

Angiotensin II Receptor Blocker (ARB)

Storage

• Conditions: Below 30°C; protect from light/moisture.

• Keep out of children's reach.