Indications:

• Treatment of hypertension
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy

Pharmacology:

• Losartan and its active metabolite block the vasoconstrictive and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor
• Hydrochlorothiazide is a thiazide diuretic that affects renal tubular mechanisms of electrolyte reabsorption

Dosage:

• Usual starting dose: 50/12.5 mg once daily
• Maximum dose: 100/25 mg once daily
• Antihypertensive effect is usually attained within three weeks after initiation of therapy

Administration:

• May be taken with or without food
• Can be administered with other antihypertensive agents

Interactions:

• No significant drug-drug interactions with Losartan Potassium have been found in interaction studies
• Thiazide diuretics may interact with alcohol, barbiturates, narcotics, antidiabetic drugs, and other antihypertensive drugs
• Absorption of Hydrochlorothiazide is impaired in the presence of anionic exchange resins

Contraindications:

• Hypersensitivity to any component of the product
• Anuria or hypersensitivity to other sulfonamide-derived drugs

Side Effects:

• Symptoms may include symptomatic hypotension, dizziness, hyperkalemia, angioedema, vertigo, gastrointestinal disturbances, and others

Pregnancy & Lactation:

• Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential; not recommended during breastfeeding

Precautions & Warnings:

• Periodic determination of serum electrolytes should be performed
• Use with caution in patients with renal impairment, hepatic impairment, and pediatric patients

Overdose Effects:

• Manifestations may include hypotension, tachycardia, bradycardia, electrolyte depletion

Therapeutic Class:

• Combined antihypertensive preparations

Storage Conditions:

• Do not store above 30°C; keep out of the reach of children

Always consult a registered healthcare professional for personalized advice before starting or changing any medication regimen.