Antigall 150

Presentation:

Antigall 150 is a tablet containing 150 mg of Ursodeoxycholic Acid (UDCA) as its active ingredient. It is typically available as a white to off-white tablet.

Indications:

Antigall 150 (Ursodeoxycholic Acid) is indicated for the treatment of various hepatobiliary disorders and for the dissolution and prevention of certain types of gallstones. Specific indications include:

• Dissolution of cholesterol gallstones (especially radiolucent gallstones in a functioning gallbladder).
• Primary Biliary Cirrhosis (PBC).
• Primary Sclerosing Cholangitis (PSC).
• Cholestasis (jaundice).
• Viral Hepatitis.
• Alcoholic Fatty Liver.
• Non-Alcoholic Steato Hepatitis (NASH).
• Prevention of gallstones during rapid weight loss.

Dosage and Administration:

The dosage of Antigall 150 varies depending on the indication, patient's weight, and individual response to treatment. It should be taken with food, usually with a glass of milk or water. It is important to adhere to the doctor's prescribed dosage and complete the full course of treatment.

Typical dosages are:

• For Dissolution of Gallstones: 8-12 mg/kg/day, often given as a single dose at night or in divided doses.
• For Primary Biliary Cirrhosis (PBC): 10-15 mg/kg/day, usually in 2-4 divided doses.
• For Acute Viral Hepatitis: 600 mg/day.
• For Alcoholic Fatty Liver: 300 mg/day.
• For Primary Sclerosing Cholangitis (PSC): 25-30 mg/kg/day.
• For Non-Alcoholic Steato Hepatitis (NASH): 13-15 mg/kg/day.

Your doctor will determine the most appropriate dosage for your condition.

Side Effects:

Commonly reported side effects of Antigall 150 include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain or discomfort
• Pruritus (itching)
• Hair loss (rare)
• Headache
• Dizziness
• Dyspepsia

Diarrhea may occur, and if it persists, you should consult your doctor. If you experience any severe or unusual side effects, seek medical attention immediately.

Precautions:

Antigall 150 should be used with caution and under medical supervision in patients with:

• Non-functioning gallbladder.
• Calcified or pigmented gallstones (as it is not effective for these types of stones).
• Inflammatory bowel disease.
• Acute inflammation of the gallbladder or biliary tract.
• Biliary obstruction or fistula.
• Liver disease (caution is advised, and liver function tests may be monitored).

Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, as¹Antigall 150 can interact with certain substances. Notably, it should not be used with:

• Drugs that increase bile cholesterol (e.g., estrogenic hormones, oral contraceptives high in estrogen).
• Bile-acid binding drugs like antacids (containing aluminum hydroxide), charcoal, or cholestyramine, as these can reduce the effectiveness of Antigall 150. If co-administration is necessary, take Antigall 150 at least 2 hours before or after these agents.

Pregnancy and Lactation:

Antigall 150 is generally considered safe for use during pregnancy (Pregnancy Category B), with no evidence of harm reported. It has been effectively used for cholestasis of pregnancy in the last trimester. It is probably safe to use during breastfeeding, but always consult your doctor before using this medication if you are pregnant or breastfeeding.

Storage:

Store Antigall 150 tablets below 25°C, protected from light and moisture. Keep the medicine out of the reach of children. Do not use after the expiry date printed on the pack.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.