Aric 20 Tablet

Aric 20 is a medication containing Istradefylline, used as an adjunct treatment for Parkinson's disease.

• Generic Name: Istradefylline

• Brand Name: Aric 20

• Manufacturer: Incepta Pharmaceuticals Ltd.

• Indication: Adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson's disease experiencing "off" episodes.

• Pharmacology: Istradefylline is a selective adenosine A2A receptor antagonist. These receptors are found in the basal ganglia, a region of the brain that suffers degeneration in Parkinson's disease, and is significantly involved in motor control.

• Dosage & Administration:

  • The recommended dosage of Istradefylline is 20 mg administered orally once daily.

  • The dosage may be increased to a maximum of 40 mg once daily, based on individual need and tolerability.

  • Patients who smoke 20 or more cigarettes per day (or the equivalent of another tobacco product): The recommended dosage is 40 mg once daily.

  • Patients with Hepatic Impairment: The maximum recommended dosage with moderate hepatic impairment is 20 mg once daily. Use of Istradefylline in patients with severe hepatic impairment should be avoided.

  • Use in Children: Safety and effectiveness of Istradefylline in pediatric patients have not been established.

• Contraindications:

  • Istradefylline is contraindicated in patients with known hypersensitivity to any component of this drug.

  • Patients with severe hepatic impairment.

• Side Effects: The most common adverse reactions are dyskinesia, dizziness, constipation, nausea, hallucination, and insomnia.

• Precautions & Warnings:

  • Monitor patients for dyskinesia or exacerbation of existing dyskinesia.

  • If hallucinations/psychotic behavior/impulse control/compulsive behaviors occur, consider dosage reduction or discontinuation of Aric.

• Drug Interactions:

  • The recommended maximum dosage of Aric with concomitant use of strong CYP 3A4 inhibitors (e.g., ketoconazole) is 20 mg once daily.

  • Avoid use with strong CYP 3A4 inducers (e.g., rifampicin).

• Pregnancy & Lactation:

  • Pregnancy: Use of Istradefylline during pregnancy is not recommended.

  • Lactation: Caution should be exercised when administered to a nursing woman.

• Overdose: There is limited clinical experience regarding human overdose. In case of an overdose, Aric treatment should be discontinued, and supportive treatment should be administered as clinically indicated.

• Storage Conditions: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.