Aride 100 Tablet

Generic Name: Amisulpride

Strength: 100mg

Presentation: Tablets

Indications:

• Acute and chronic schizophrenic disorders, particularly those with positive symptoms (delusions, hallucinations, thought disorders) and/or negative symptoms (blunted affect, emotional and social withdrawal).

Dosage and Administration:

• Adults:

  • For acute psychotic episodes, the recommended oral dose is 400 mg to 800 mg daily, divided into two doses.

  • The daily dose may be increased up to 1200 mg/day in individual cases. Doses above 800 mg/day are not shown to be more effective and may increase adverse events.

  • Dosage should be adjusted according to individual response.

• For patients with mixed positive and negative symptoms, doses should be adjusted to achieve optimal control of positive symptoms.

• Patients with predominantly negative symptoms: Oral doses of 50 mg to 300 mg daily are recommended. Dosage should be adjusted individually.

• The medicine should be taken as advised by the doctor.

Contraindications:

• Hypersensitivity to amisulpride or any other ingredients in the formulation.

• Prolactin-dependent tumors (e.g., pituitary gland prolactinomas, breast cancer).

• Pheochromocytoma.

• Children up to puberty.

• Pregnancy and lactation.

• Combination with MAOIs.

Warnings and Precautions:

• Neuroleptic Malignant Syndrome (NMS): A potentially fatal syndrome associated with antipsychotic drugs, including Aride. Discontinue all antipsychotics, including Aride, if NMS is suspected.

• Seizures: Aride can lower the seizure threshold. Monitor patients with a history of seizures closely.

• Withdrawal Symptoms: Involuntary movement disorders (akathisia, dystonia, dyskinesia) have been reported following abrupt cessation of high doses of antipsychotics. Gradual withdrawal is recommended.

• Prolactin Levels: Aride may increase plasma prolactin levels, leading to galactorrhea, amenorrhea, gynecomastia, breast pain, orgasmic dysfunction, and impotence.

• QT Interval Prolongation: Use with caution in patients with cardiovascular disease, a family history of QT prolongation, hypokalemia, and other risk factors for QT prolongation.

• Elderly Patients: Use with caution due to the potential risk of hypotension or sedation.

• Renal Impairment: Dose adjustment is recommended.

• Liver Impairment:

• Pregnancy: Aride should be used during pregnancy only if the potential benefits justify the potential risks.

• Lactation: Aride is found in breast milk and is contraindicated during breastfeeding.

• Others:

  • Increased mortality in elderly patients with dementia-related psychosis.

  • Potential for venous thromboembolism.

  • Leukopenia, neutropenia, and agranulocytosis have been reported.

  • Hyperglycemia and impaired glucose tolerance.

Drug Interactions:

• Contraindicated:

  • MAOIs

• Not Recommended:

  • Levodopa