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For symptomatic management of osteoarthritis
Symptomatic treatment of osteoarthritis
Adjunctive support for joint mobility in sports injuries
Not for acute inflammatory conditions or rheumatoid arthritis
Per Film-Coated Tablet:
Glucosamine Sulfate: 600 mg
Chondroitin Sulfate: 750 mg
| Component | Mechanism | Clinical Effect |
|---|---|---|
| Glucosamine | Precursor for glycosaminoglycans → stimulates cartilage matrix synthesis | Improves joint cushioning and repair |
| Chondroitin | Inhibits cartilage-degrading enzymes → enhances proteoglycan retention | Reduces friction, improves lubrication |
| Synergistic Outcome: Reduced pain, improved joint function, and slowed structural degeneration. |
Adults: 1 tablet 2–3 times daily with meals
Minimum Therapeutic Course: 3 months for clinical benefit
| Body Weight | Daily Glucosamine | Daily Chondroitin | Tablets/Day* |
|---|---|---|---|
| <54 kg | 1000 mg | 800 mg | 1.5–2 |
| 54–91 kg | 1500 mg | 1200 mg | 2–3 |
| >91 kg | 2000 mg | 1600 mg | 3–4 |
*Based on 600mg/750mg per tablet; round to nearest whole tablet
Key Notes:
Swallow whole with food (enhances absorption)
Onset of effect: 2–8 weeks
Do not crush/chew
Hypersensitivity to shellfish/sulfur-containing compounds
Concomitant use with anticoagulants (unless closely monitored)
GI-Related (≥5%):
Nausea • Diarrhea • Constipation • Heartburn • Epigastric pain
Less Common:
Edema (eyelid/limbs) • Transient alopecia • Skin reactions
Extrasystoles (rare)
Diabetes:
Monitor blood glucose (may cause insulin resistance)
Anticoagulant Therapy:
Check INR weekly (potentiates warfarin/heparin)
Ocular Effects:
Screen for elevated intraocular pressure (glaucoma risk)
Special Populations:
Pregnancy/Lactation: Contraindicated (insufficient safety data)
Renal/Hepatic Impairment: Use with caution
| Drug Class | Effect | Management |
|---|---|---|
| Anticoagulants | ↑ Bleeding risk (INR elevation) | Monitor INR; adjust warfarin dose |
| Antidiabetics | ↓ Glycemic control | Increase glucose monitoring |
| NSAIDs | Theoretical synergy (no clinical data) | No dose adjustment needed |
Compliance: Benefits manifest after 4+ weeks of continuous use
Food Timing: Always take with meals to reduce GI upset
Diabetic Alert: Report unexplained hyperglycemia
Emergency Situations:
Discontinue 2 weeks pre-surgery (bleeding risk)
Nutraceutical / Symptomatic Slow-Acting Drug for Osteoarthritis (SYSADOA)
Below 25°C • Protect from moisture • Shelf life: 36 months
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