💊 Candicon (Voriconazole) Summary

Candicon is a potent triazole antifungal used for serious, deep-seated fungal infections in patients aged 12 years and older.

📋 Key Indications

• Invasive Aspergillosis: Serious lung/systemic fungal infection.
• Candidiasis: Deep tissue infections (kidney, bladder, abdomen) and esophageal thrush.
• Rare Pathogens: Infections caused by Scedosporium or Fusarium species.
• Refractory Cases: For patients who do not respond to other antifungal therapies.

🥄 Dosage & Administration

Oral Intake: Must be taken at least 1 hour before or 1 hour after a meal.

• Adults (≥40 kg):
  • First 24 hours: 400 mg every 12 hours.
  • Maintenance: 200 mg twice daily.
• Adults (<40 kg):
  • First 24 hours: 200 mg every 12 hours.
  • Maintenance: 100 mg twice daily.

⚠️ Safety & Interactions

• Side Effects: Commonly includes blurred vision, headache, nausea, and abdominal pain.
• Drug Interactions: 🛑 Critical warning. Do not use with drugs like Terfenadine, Sirolimus, Rifampin, or Carbamazepine. It interacts with many medications processed by the liver (CYP450).
• Skin Health: Long-term use (>180 days) increases the risk of Squamous cell carcinoma (skin cancer). Use sun protection.

🤰 Pregnancy & Lactation

• Only use during pregnancy if the benefit clearly outweighs the risk to the fetus.
• Use under strict medical supervision while breastfeeding.

📦 Storage & Reconstitution

• Suspension: Add 25 ml of boiled and cooled water. Shake vigorously.
• Storage: Store dry powder at 2°C–8°C. Once mixed, store between 15°C–30°C and discard after 14 days.
• Keep away from light and children. 🚫👶