Indications

Celofen (Aceclofenac) is indicated for the relief of pain and inflammation associated with:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Toothache
• Trauma
• Lumbago

Pharmacology

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with both anti-inflammatory and analgesic (pain-relieving) properties. It works by acting as a potent inhibitor of the cyclooxygenase (COX) enzyme, which is responsible for the production of prostaglandins—chemicals that cause pain and inflammation. After oral administration, it is rapidly and completely absorbed.

Dosage & Administration

• Extended Release Tablet: The recommended dose for adults is one 200 mg tablet once daily.
• Film Coated Tablet: The recommended dose for adults is 100 mg twice daily.

Interaction

While no significant drug interactions have been observed, close monitoring is required when Celofen is used with the following:

• Lithium and Digoxin: May increase the plasma concentration of these drugs.
• Diuretics: May interfere with the activity of diuretics.
• Anticoagulants: May enhance the anticoagulant effect.
• Methotrexate: May increase the plasma level of methotrexate.

Contraindications

Celofen is contraindicated in patients with:

• Known hypersensitivity to Aceclofenac.
• Patients in whom aspirin or other NSAIDs have triggered asthma attacks.

Side Effects

The provided text contains a repetition of the pharmacology section and does not list specific side effects. However, as an NSAID, potential side effects often include gastrointestinal issues.

Pregnancy & Lactation

The use of Aceclofenac should be avoided during pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus.

Precautions & Warnings

Caution should be exercised when prescribing Celofen to patients with:

• Active or suspected peptic ulcer or gastrointestinal bleeding.
• Moderate to severe hepatic (liver) impairment.
• Cardiac or renal (kidney) impairment.
• Patients who suffer from dizziness or urticaria (hives).

Use in Special Populations

There are no clinical data available on the use of Celofen in children.

Therapeutic Class

Celofen belongs to the therapeutic class of drugs for Osteoarthritis, drugs for Rheumatoid Arthritis, and Non-steroidal Anti-inflammatory Drugs (NSAIDs).

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.