Convules Syrup - (200mg/5ml)

Generic Name: Sodium Valproate

Strength: Each 5 ml contains Sodium Valproate BP equivalent to Valproic Acid 200 mg.

Indications:

Convules Syrup is used to treat various types of seizures, including:

• Generalized tonic-clonic seizures (grand mal).
• Absence seizures (petit mal).
• Myoclonic seizures.
• Partial seizures.
• It may also be used in the treatment of manic episodes associated with bipolar disorder.

Dosage and Administration:

Dosage should be individualized by a physician based on the patient's age, weight, and the condition being treated.

• Epilepsy:
  • Adults and Children over 10 years: Initial dose is usually 10-15 mg/kg/day, increased at weekly intervals by 5-10 mg/kg/day until seizures are controlled or side effects preclude further increase. Maximum recommended dose is 30 mg/kg/day.
  • Children under 10 years: Initial dose is usually 20 mg/kg/day in divided doses. Maintenance dose is usually 20-30 mg/kg/day.
• Bipolar Disorder (Manic Episodes):
  • Initial dose is usually 750 mg daily in divided doses. Dosage should be increased as rapidly as possible to achieve a therapeutic response or desired plasma level. Maximum recommended dose is 60 mg/kg/day.

Convules Syrup should be taken orally, preferably with or after meals to reduce gastrointestinal upset. Use the provided measuring device for accurate dosing.

Contraindications:

• Hypersensitivity to valproate or any of its components.
• Patients with hepatic disease or significant hepatic dysfunction.
• Known urea cycle disorders.
• Porphyria.
• Mitochondrial disorders caused by mutations in the nuclear gene encoding the mitochondrial polymerase γ (POLG) and children under two years of age who are suspected of having a POLG-related disorder.

Side Effects:

• Very Common: Nausea, vomiting, diarrhea.
• Common: Increased appetite and weight gain, transient hair loss, tremor, drowsiness, dizziness, headache.
• Less Common: Thrombocytopenia (low platelet count), pancreatitis, liver dysfunction.
• Rare: Severe hepatic failure, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Precautions:

• Hepatic failure resulting in fatalities has occurred. Monitor liver function prior to therapy and at frequent intervals thereafter.
• May cause drowsiness or dizziness, affecting the ability to drive or operate machinery.
• Avoid alcohol consumption.
• Monitor for signs and symptoms of pancreatitis.
• May decrease platelet counts and inhibit platelet aggregation.
• Hyperammonemia (elevated ammonia levels) can occur.
• Monitor for suicidal thoughts or behavior.
• Drug interactions can occur with other anticonvulsants, aspirin, warfarin, and certain other medications. Inform your doctor about all medications you are taking.

Use in Pregnancy & Lactation:

• Pregnancy: Valproate can cause serious birth defects. It is contraindicated for use in pregnant women unless other medications have been ineffective or are not tolerated. Women of childbearing potential should use effective contraception.
• Lactation: Valproate is excreted in breast milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.

Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.