Dexend 60 

Presentation: Each capsule contains Dexlansoprazole 60 mg. Dexend 60 is a product of Labaid Pharma Ltd. in Bangladesh and is usually available in blister packs. The capsule contains a Dual Delayed Release (DDR) formulation with enteric-coated granules designed for a dual release profile.

Indications: Dexend (Dexlansoprazole) is a proton pump inhibitor (PPI) indicated for:

• Healing of all grades of erosive esophagitis (EE) for up to 8 weeks.  
• Maintaining healing of EE and relief of heartburn for up to 6 months.  
• Treatment of heartburn associated with symptomatic non-erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.  

Dosage and Administration:   Dexend 60 capsules should be swallowed whole and can be taken without regard to food. Alternatively, the capsule can be opened, and the intact granules sprinkled on one tablespoon of applesauce and swallowed immediately. Granules should not be chewed.

• Healing of Erosive Esophagitis:60 mg once daily for up to 8 weeks.  
• Maintenance of Healed Erosive Esophagitis and Relief of Heartburn:30 mg oncedaily.  
• Symptomatic Non-Erosive GERD:30 mg once daily for 4weeks.

No dosage adjustment is usually needed for the elderly or in patients with mild renal or hepatic impairment. A maximum daily dose of 30 mg should be considered for patients with moderate hepatic impairment. Dexlansoprazole is not recommended for patients with severe hepatic impairment.

Side Effects: Common side effects of Dexend (Dexlansoprazole) may include diarrhoea, abdominal pain, nausea, vomiting, and flatulence.

Less common side effects may include headache and other gastrointestinal disturbances. Long-term use of PPIs may be associated with an increased risk of bone fracture, hypomagnesaemia, and vitamin B12 deficiency.

Precautions: Dexend (Dexlansoprazole) is contraindicated in patients with known hypersensitivity to any component of the formulation. Gastric malignancy should be excluded before initiating therapy.

Caution should be exercised in patients with moderate hepatic impairment. Dexlansoprazole may interact with other drugs, including atazanavir, warfarin, tacrolimus, clopidogrel, and methotrexate. It's important to inform your doctor about all medications you are currently taking.

Use in Pregnancy and Lactation: There are no adequate and well-controlled studies with Dexlansoprazole in pregnant women. Dexend should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. It is not known whether⁵Dexlansoprazole is excreted in human milk. Caution should be exercised when administering Dexend to a nursing mother.

Storage: Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.