Ebatin 10: A Non-Sedating Antihistamine

Ebatin 10 contains Ebastine, a long-acting and selective H1-histamine receptor antagonist. It is used for the symptomatic treatment of allergic conditions like allergic rhinitis and chronic urticaria.

How Ebatin 10 Works (Pharmacology)

Ebastine is a selective H1-histamine receptor antagonist. After oral administration, it is rapidly absorbed and undergoes extensive first-pass metabolism, almost completely converting into its pharmacologically active acid metabolite, carebastine. This active metabolite then inhibits peripheral H1-histamine receptors, thereby reducing allergic reactions like itching, sneezing, and watery eyes. The inhibition of these receptors remains constant after repeated administration, providing sustained relief.

Key Indications & Benefits

Ebatin is indicated for the symptomatic treatment of:

• Seasonal allergic rhinitis: Allergic reactions that occur during specific seasons, often due to pollen.
• Perennial allergic rhinitis: Allergic reactions that occur year-round, often due to allergens like dust mites or pet dander.
• Chronic idiopathic urticaria: Chronic hives (itchy red welts on the skin) where the cause is unknown.

Dosage & Administration

Ebatin may be taken with or without food. Always consult a registered physician for medication use.

Tablet:

• Adults (more than 12 years of age): 10 mg (one tablet) once daily.
• Children (6-12 years of age): 5 mg (half tablet) once daily.

Syrup:

• Children (2-5 years of age): 2.5 ml once daily (up to 5 ml in severe cases such as Perennial Allergic Rhinitis).
• Children (6-12 years of age): 5 ml once daily (up to 10 ml in severe cases such as Perennial Allergic Rhinitis).

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before taking Ebatin 10.

Contraindications:

• Patients with a known hypersensitivity to Ebastine or any of its ingredients.

Side Effects:

• Most common: Headache, dry mouth, and drowsiness.
• Less commonly reported: Abdominal pain, dyspepsia (indigestion), nausea, and insomnia.

Interactions:

• Ketoconazole or Erythromycin: Concomitant use with Ebatin leads to increased plasma levels of Ebatin and a prolonged QTc interval (a heart rhythm abnormality). This combination should be used with caution or avoided.
• Ebatin does not significantly interact with the pharmacokinetics of theophylline, warfarin, cimetidine, or diazepam.
• The sedation effect of alcohol and diazepam may be enhanced when taken with Ebatin.

Overdose Effects:

• No clinically meaningful signs or symptoms were observed with doses up to 100 mg given once daily.
• There is no specific antidote for Ebatin overdose.
• In case of accidental overdose, gastric lavage (stomach pumping), monitoring of vital functions (including ECG), and symptomatic treatment should be carried out.

Storage Conditions

Store below 30°C at a cool and dry place, away from light. Keep out of reach of children.