Empamet XR 5/1000

Presentation: Each extended-release tablet contains Empagliflozin INN 5 mg and Metformin Hydrochloride BP 1000 mg. Available in strips.

Indications: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both empagliflozin and metformin is appropriate.

Dosage and Administration: The dosage should be individualized based on the patient's current regimen, glycemic control, and tolerability, not exceeding the maximum recommended daily dose of empagliflozin 25 mg and metformin 2000 mg. Usually taken once daily with a meal. In patients not currently treated with metformin, the starting dose is one tablet once daily with a meal. In patients already on metformin, the starting dose should provide empagliflozin 5 mg once daily and maintain the same total daily dose of metformin. Swallow whole with water; do not crush, cut, or chew. Dose escalation should be gradual to reduce gastrointestinal side effects associated with metformin.

Side Effects: Common side effects may include nausea, vomiting, diarrhea, headache, and increased urination. Hypoglycemia may occur when used in combination with insulin or sulfonylureas. Genital infections and urinary tract infections have also been reported.

Precautions: Contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute metabolic acidosis, diabetic ketoacidosis, and known hypersensitivity to empagliflozin or metformin. Not recommended to initiate treatment in patients with eGFR between 30-45 mL/min/1.73 m². Use with caution in patients with moderate renal impairment, history of pancreatitis, and heart failure. Temporary discontinuation may be required for surgical procedures or radiological examinations involving iodinated contrast media. Avoid excessive alcohol intake.

Storage: Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.