Encorate Chrono 300

Presentation: Each controlled-release tablet contains Sodium Valproate BP 200 mg and Valproic Acid BP 87 mg (equivalent to Sodium Valproate 300 mg). 

Indications: Encorate Chrono is indicated for the treatment of various forms of epilepsy, including generalized tonic-clonic seizures, absence seizures, and partial seizures. It is also used for the treatment of manic episodes in bipolar disorder and for the prophylaxis of migraine headaches.

Dosage and Administration: The dosage is individualized and determined by the physician based on the patient's condition, age, weight, and response to treatment.

• Epilepsy:
  • Adults: The usual starting dose is 600 mg daily, administered in one or two divided doses, preferably with or after food. The dosage may be increased by 200 mg every 3 days until seizure control is achieved. The usual maintenance dose ranges from 1000 to 2000 mg daily.
  • Children (over 20 kg): The usual starting dose is 400 mg daily in divided doses, which may be increased gradually until seizure control is achieved, typically within the range of 20-30 mg/kg daily.
• Mania: The initial dose is usually 600 mg daily. Dosage may be increased rapidly to achieve therapeutic effect and may be adjusted up to 2500 mg daily based on clinical response.
• Migraine Prophylaxis: The usual starting dose is 200-300 mg twice daily.

Encorate Chrono tablets are designed for controlled release and should be swallowed whole; they should not be crushed or chewed. It is generally recommended to take this medication with or after food to minimize gastrointestinal upset. Follow your physician's instructions carefully regarding the dose and timing of administration.

Side Effects: Common side effects may include nausea, vomiting, indigestion, diarrhea, constipation, increased or decreased appetite, weight gain, transient hair loss, tremor, and drowsiness. Less common side effects can include ataxia (lack of coordination), headache, dizziness, confusion, and changes in liver function tests. Rare but serious side effects may include severe liver damage, pancreatitis, and blood disorders.

Precautions: Inform your physician if you have a history of liver disease, kidney disease, bleeding disorders, mitochondrial disorders, or a family history of liver dysfunction. Valproate should not be used during pregnancy unless clearly needed, as it can cause serious birth defects. Women of childbearing potential should use effective contraception. Breastfeeding is generally not recommended while taking valproate.

Valproate may interact with other medications, including other antiepileptic drugs (e.g., phenytoin, phenobarbital, carbamazepine), certain antidepressants, and anticoagulants. Inform your physician about all medications you are currently taking.

This medication may cause drowsiness; caution should be exercised while driving or operating machinery until you know how it affects you. Regular monitoring of liver function and blood counts may be required during treatment. Avoid abrupt discontinuation of this medication.

Storage: Store Encorate Chrono 300 tablets below 30°C in a dry place, protected from light. Keep this medicine out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.