💊 Febustat (Febuxostat) Summary

Febustat is a selective inhibitor used for the chronic management of high uric acid levels (hyperuricemia) in patients with gout.

📋 Indications

• Chronic Gout Management: Lowers uric acid to prevent gout attacks.

• Tumor Lysis Syndrome: Used at higher doses (120 mg) during chemotherapy.

• ⚠️ Note: It is not recommended for patients with high uric acid who do not have symptoms.

🥄 Dosage & Administration

• Standard Start: 40 mg once daily.

• Titration: If uric acid remains above 6 mg/dL after 2 weeks, the dose may be increased to 80 mg. Further increase to 120 mg is possible if needed.

• Gout Flares: When you first start Febustat, you might experience a flare-up. Doctors usually prescribe Colchicine or an NSAID alongside Febustat for the first few months to prevent this.

⚠️ Safety & Side Effects

• Common Side Effects: Gout flares, diarrhea, nausea, headache, and liver function abnormalities.

• Contraindications: 🛑 Do not use if you are taking Azathioprine, Mercaptopurine, or Theophylline, as it can lead to dangerous toxicity.

• Cardiovascular Warning: Monitor for signs of heart attack or stroke, as a higher rate of these events has been observed compared to other gout medications.

• Liver Health: Periodically monitor liver enzymes (tests), as elevations can occur.

🤰 Pregnancy & Lactation

• Category C: Use during pregnancy only if the benefits outweigh the risks.

• Breastfeeding: It is unknown if it passes into milk; use with caution.

📦 Storage

• Store below 30°C in a dry, dark place.

• Keep out of reach of children. 🚫👶