Gabarol 25 Capsule contains Pregabalin 25mg. It is manufactured by ACI Limited in Bangladesh.

Indications: Pregabalin is used for:

• Neuropathic pain associated with diabetic peripheral neuropathy.
• Postherpetic neuralgia (nerve pain after shingles).
• Adjunctive therapy for partial-onset seizures in adults and children (1 month and older).
• Fibromyalgia (widespread muscle pain and fatigue).
• Neuropathic pain associated with spinal cord injury.

Pharmacology: Pregabalin is a structural derivative of the neurotransmitter gamma-aminobutyric acid (GABA). It binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. While its exact mechanism isn't fully understood, this binding is thought to reduce the release of certain neurotransmitters involved in pain and seizure activity.

Dosage and Administration: The dosage of Gabarol 25 will be determined by your doctor based on your specific condition, kidney function, and response to treatment. It is usually taken orally, with or without food.

General starting doses for adults may include:

• Neuropathic pain: Typically starts at 150 mg per day, divided into two or three doses.
• Epilepsy: Usually starts at 150 mg per day, divided into two or three doses.
• Fibromyalgia: Usually starts at 150 mg per day, divided into two doses.

The dose may be gradually increased by your doctor as needed, up to a maximum of 600 mg per day.

Side Effects: Common side effects of Pregabalin may include:

• Dizziness
• Drowsiness
• Blurred vision
• Double vision
• Difficulty with coordination
• Dry mouth
• Weight gain
• Swelling in the arms or legs
• Difficulty concentrating
• Increased appetite

Less common but potentially serious side effects can occur. It's important to contact your doctor immediately if you experience:

• Severe allergic reaction (rash, itching, swelling, difficulty breathing)
• Swelling of the face, lips, tongue, or throat (angioedema)
• Suicidal thoughts or behavior
• Changes in vision
• Unexplained muscle pain, tenderness, or weakness
• Shortness of breath

Precautions:

• Inform your doctor if you have any kidney problems, heart problems, or a history of mood disorders or suicidal thoughts.
• Pregabalin may cause drowsiness and dizziness, so use caution while driving or operating machinery until you know how it affects you.
• Avoid alcohol while taking Pregabalin as it can increase drowsiness.
• Do not stop taking Pregabalin suddenly, as this may lead to withdrawal symptoms. Your doctor will guide you on how to gradually discontinue the medication.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug Interactions: Pregabalin can interact with other medications. Inform your doctor about all the medicines you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, especially:

• Opioid pain medications
• Benzodiazepines (e.g., diazepam, lorazepam)
• Alcohol
• Certain antihistamines

Storage: Store Gabarol 25 capsules in a cool and dry place, away from light and moisture, and out of reach of children. The temperature should generally be kept below 30°C.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.