Glymin 850 

Presentation:Glymin 850 Tablet, available in Bangladesh, contains Metformin Hydrochloride BP 850 mg. 

Indications:Glymin is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight and obese adults, when dietary management and exercise alone have not been sufficient to achieve adequate glycemic control.Glymin can be used as monotherapy or in combination with other oral antidiabetic agents or with insulin.It is also indicated for use in children aged 10 years and older and adolescents as monotherapy or in combination with insulin.  

Dosage and Administration:The dosage of Glymin must be individualized based on the patient's blood glucose levels and tolerability, using the lowest effective dose.It should be taken orally with meals to reduce gastrointestinal side effects.  

• Adults:The usual starting dose is 500 mg twice a day or 850 mg once a day, given with or after meals.Dosage adjustments should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a maximum daily dose of 2000 mg per day, given in divided doses. Patients requiring further glycemic control may be given up to a maximum daily dose of 2550 mg per day, usually administered as 850 mg three times a day with meals.
• Children (10 years and older) and Adolescents: The usual starting dose is 500 mg twice a day, given with or after meals. Dosage increases should be made in increments of 500 mg weekly up to a maximum daily dose of 2000 mg per day, given in divided doses.

Side Effects:The most common side effects are gastrointestinal disturbances, especially at the beginning of treatment.These may include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.⁹These symptoms usually resolve spontaneously.A metallic taste may also occur.Long-term use of metformin may lead to decreased absorption of vitamin B12.Lactic acidosis is a rare but serious metabolic complication that can occur due to metformin accumulation, especially in patients with renal impairment.

Precautions: Glymin is contraindicated in patients with:

• Known hypersensitivity to metformin hydrochloride.
• Severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m²).
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma. 
• A history of lactic acidosis.
• Acute conditions with the potential to alter renal function, such as dehydration, severe infection, shock. 
• Acute or chronic disease which may cause tissue hypoxia, such as cardiac or respiratory failure, recent myocardial infarction. 
• Severe hepatic impairment.
• Acute alcohol intoxication, alcoholism.

Caution should be exercised in patients with moderate renal impairment (eGFR 30-59 mL/min/1.73 m²), heart failure, and elderly patients. Metformin therapy should be temporarily discontinued before any intravascular administration of iodinated contrast media and before major surgery with expected prolonged fasting.  

Storage:Store Glymin 850 tablets in a cool (below 30°C) and dry place, protected from light and moisture.Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.