Hemorif DS (Diosmin & Hesperidin): A Phlebotonic and Vascular Protecting Agent

Hemorif DS contains a micronized combination of Diosmin and Hesperidin. It is indicated for the treatment of acute and chronic hemorrhoidal attacks, as well as chronic venous insufficiency of the lower limbs. Its primary function is to reinforce venous tone and protect the microcirculation. Hemorif DS belongs to the therapeutic class of Phlebotonic and Vascular protecting preparations.

How Hemorif DS Works (Pharmacology)

Diosmin and Hesperidin work together to improve blood vessel health:

• Reinforces Venous Tone: The drug prolongs the activity of noradrenaline on the venous walls. This decreases venous capacitance (the ability of a vein to hold blood), venous distensibility (how much it can stretch), and venous emptying time, which helps to improve blood flow.
• Protects Microcirculation: It fights against microcirculation damage by decreasing leukocyte activation, which in turn inhibits the release of inflammatory mediators like free radicals and prostaglandins. This action normalizes capillary permeability and strengthens capillary resistance.
• Improves Lymphatic Drainage: It acts on the lymphatic system by increasing lymph flow and lymph oncotic pressure, which helps to reduce fluid buildup and swelling.

Key Indications & Benefits

Hemorif DS is indicated for the treatment of:

• Acute hemorrhoidal attacks.
• Chronic hemorrhoidal disease.
• Chronic venous insufficiency of the lower limbs, characterized by symptoms like heavy legs, pain, and nocturnal cramps.

Dosage & Administration

Hemorif DS is available in two strengths. The tablets should be taken at meal times. The dosage varies with the condition being treated and the strength of the tablet. Always consult a registered physician for specific dosage instructions.

• For Acute Hemorrhoids (DS tablet): 1 tablet three times daily for the first 4 days, followed by 1 tablet twice daily for 3 days. A maintenance dose may be 1 tablet once daily.
• For Chronic Hemorrhoids (DS tablet): 1 tablet once daily for 3 months.
• For Chronic Venous Insufficiency (DS tablet): 1 tablet once daily for 2-6 months.
• For Acute Hemorrhoids (450mg/50mg tablet): 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for 3 days. A maintenance dose is 1 tablet twice daily.
• For Chronic Hemorrhoids/Venous Insufficiency (450mg/50mg tablet): 1 tablet twice daily.

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before taking Hemorif DS.

Contraindications:

• Known hypersensitivity to any of the ingredients.
• It is important that chronic venous insufficiency and its complications are diagnosed and monitored by a physician.

Side Effects:

• Rare: Routine gastric disorders and neurovegetative disorders (such as a feeling of discomfort) have been reported. These are generally mild and do not require discontinuation of treatment.

Pregnancy & Lactation:

• Pregnancy: While experimental studies in animals have not shown any harmful effects, and no harmful effects have been reported in humans, it should still be used under a doctor's guidance.
• Lactation: It is not recommended for use in nursing mothers due to the absence of data regarding its excretion into breast milk.

Precautions & Warnings:

• Hemorrhoidal Symptoms: If symptoms do not improve within 15 days, a doctor should be consulted.
• Cancer: As a precaution, it is not recommended for patients with a history of cancer, as no specific studies have been performed in this population.

Drug Interactions:

• No evidence of drug incompatibility has been reported in clinical trials.

Storage Conditions

Keep below 30°C, away from light and moisture. Keep out of the reach of children.