Informet XR 500

Presentation:Each extended-release tablet contains 500 mg of metformin hydrochloride.

Indications: Informet XR 500 is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It may be used as monotherapy orin combination with other oral antidiabetic agents or with insulin.  

Dosage and Administration: The usual starting dose of Informet XR is 500 mg once daily with the evening meal. Dosage may be increased gradually in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal, or alternatively, 1000 mg twice daily taken with meals.The tablet should be swallowed whole and not crushed, cut, or chewed.Dosage should be individualized based on effectiveness and tolerability. Renal function should be assessed prior to initiation and periodically thereafter.  

Side Effects:Common side effects may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.These are often transient and may decrease over time. Less common side effects include taste disturbance. Prolonged use may lead to Vitamin B12 deficiency.Lactic acidosis is a rare but serious potential side effect requiring immediate medical attention.  

Precautions:Informet XR 500 is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute metabolic acidosis, including diabetic ketoacidosis, and known hypersensitivity to metformin.It is not recommended in patients with hepatic impairment, acute alcohol intoxication, or conditions associated with tissue hypoxia.Caution should be exercised in patients with moderate renal impairment and in elderly patients. Alcohol consumption should be avoided or limited.

Storage:Store below 30°C, protected from light and moisture.Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.