Isoben: Antimicrobial Emollient for Dry, Itchy Skin Conditions

Isoben is an antimicrobial emollient available as both a lotion and a cream. It is indicated for the management of dry and pruritic (itchy) skin conditions, especially eczema and dermatitis. It can be used for direct application to the skin and as a soap substitute. It belongs to the therapeutic class of miscellaneous topical agents.

Composition

Isoben Lotion (per gram):

• Liquid Paraffin BP: 25 mg
• Benzalkonium Chloride USP: 1 mg
• Chlorhexidine Hydrochloride BP: 1 mg
• Isopropyl Myristate BP: 25 mg

Isoben Cream (per gram):

• Liquid Paraffin BP: 100 mg
• Benzalkonium Chloride USP: 1 mg
• Chlorhexidine Hydrochloride BP: 1 mg
• Isopropyl Myristate BP: 100 mg

How Isoben Works (Pharmacology)

Isoben contains two types of active ingredients that work together to manage dry and pruritic skin:

1. Antimicrobials (Benzalkonium Chloride and Chlorhexidine Dihydrochloride):
   • Help to combat bacteria on the skin that can worsen eczema.
   • Prevent infection caused by scratching itchy skin.
2. Emollients (Liquid Paraffin and Isopropyl Myristate):
   • Soften, moisturize, and protect the skin by trapping moisture and restoring its normal protective function.
   • Prevent skin-drying and irritant effects often caused by ordinary soaps, foaming additives, and fragrances used in cleansing products.

Isoben can be used in addition to other emollients or treatments prescribed by a doctor or pharmacist for dry skin conditions.

Dosage & Administration

For maximum benefit, use Isoben regularly and as often as required. Always consult a registered physician for medication use.

• Adults, Children, and the Elderly:
  • For application to the skin: Apply the lotion/cream to the affected areas as required. Massage into the skin until absorbed. Do not rub vigorously. Reapply as often as required. If applying another treatment, apply alternately, leaving sufficient time for each product to soak in.
  • For use as a soap substitute: Use this lotion/cream to wash with instead of ordinary soap or shower gel. It will not foam or lather. After washing, pat the skin dry with a soft towel (avoid rubbing).

Instructions for 500 ml bottle with pump dispenser:

• Turn the top of the pump dispenser anti-clockwise to unlock.
• Press down the pump dispenser several times to prime it before the first use.
• These instructions apply to all age groups.

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before using Isoben.

Contraindications:

• If you are allergic (hypersensitive) to benzalkonium chloride, chlorhexidine dihydrochloride, liquid paraffin, isopropyl myristate, or any of the other ingredients.

Side Effects:

• Most people do not experience side effects.
• Stop using and seek urgent medical help if you experience signs of a serious allergic reaction (rare but possible): Swelling of the face, lips, tongue or throat; sudden uncharacteristic red itchy skin rash (hives) away from the application site; wheezing or breathing difficulty; feeling faint or dizzy; a strange metallic taste in the mouth; or collapse.
• Rarely: Skin reactions on treated areas (redness, irritation, and/or itching) may occur. These reactions may be more significant with excessive use as a leave-on application in skin folds (e.g., groin, nappy area).

Pregnancy & Lactation:

• This product can be used during pregnancy and while breastfeeding.
• Ingredients have been widely used for many years without reported problems, though specific safety trials have not been conducted.

Precautions & Warnings:

• Severe Allergic Reactions (Chlorhexidine): Very rare reports of severe generalized allergic reactions (e.g., drop in blood pressure, unconsciousness) have been associated with chlorhexidine-containing products in susceptible individuals.Do not use if you have had problems with chlorhexidine-containing products in the past.
• Fire Hazard:Do not smoke or go near naked flames. Fabric (clothing, bedding, dressings, etc.) that has been in contact with Isoben burns more easily and is a serious fire hazard. Washing may reduce product build-up but not totally remove it.
• Test Area (for very sensitive skin): It is advisable to start any new treatment on a small test area first, especially when treating the face or young children.
• Avoid Eyes: Avoid getting the product in the eyes, especially when applying to the face.
• Slippery Surfaces: When used as a soap substitute in the bath or shower, the product can make surfaces slippery. Use caution to avoid slipping (e.g., use a bath mat).
• Cetostearyl Alcohol: May cause local skin reactions (e.g., contact dermatitis). If you have previously reacted to any ingredients, consult your doctor.

Drug Interactions:

• Isoben is not known to affect, or be affected by, other medicines.

Storage Conditions

Store in a cool and dry place, protect from light, and do not store above 25°C. Keep out of children's reach. For external use only.