Product Overview

Maczith 200mg/5ml Suspension is a broad-spectrum macrolide antibiotic effective against respiratory, skin/soft tissue, ear, and sexually transmitted infections in adults and children. Its unique pharmacokinetics allow short-course dosing for enhanced compliance.

Key Uses

Treats bacterial infections caused by susceptible organisms:

• Pediatric Focus: Ear infections (otitis media), pneumonia, strep throat, sinusitis

• Adult & Pediatric: Skin/soft tissue infections, typhoid fever*

• STIs: Uncomplicated gonorrhea, chlamydial urethritis/cervicitis

*Off-label use for typhoid; confirm local guidelines

Mechanism of Action

Azithromycin binds to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis and stopping bacterial growth without affecting human cells.

Dosage Guide

Pediatric Suspension (≥6 months)

Special Cases

• Strep Throat: 12 mg/kg daily × 5 days

• Typhoid Fever: 20 mg/kg daily × 7-10 days

Shake bottle well before use. Use provided measuring cup.

Administration

1. Preparation:

   • Shake bottle → Add cooled boiled water to marked line → Shake vigorously until dissolved.

2. Timing:

   • Take 1 hour before or 2 hours after food/antacids.

3. Storage:

   • Use within 10 days of mixing. Keep refrigerated (2-8°C).

Safety Profile

✅ Safe For

• Renal impairment: No dose adjustment needed

• Elderly: Standard dosing

⚠️ Contraindications

• Hypersensitivity to macrolides

• Hepatic disease

• Concurrent pimozide or ergot derivatives

Common Side Effects

Nausea (33%), diarrhea (19%), abdominal pain (27%), vomiting (7%) – typically mild and transient.

Serious Risks (Rare)

• Severe allergic reactions (anaphylaxis, angioedema)

• Cholestatic jaundice

• QT prolongation (in high-risk patients)

Special Populations

• Pregnancy (Category B): Use only if benefits outweigh risks

• Breastfeeding: Monitor infants for diarrhea/vomiting

• Hepatic Impairment: Avoid (primary excretion route)

Drug Interactions

Overdose Management

Symptoms: Severe nausea, vomiting, diarrhea, temporary hearing loss  
Treatment: Gastric lavage + supportive care

Patient Tips

• ✔️ Complete full course – even if symptoms improve.

• ⚠️ Report immediately: Rash, breathing difficulties, or yellowing eyes/skin.

• ⏱️ Missed dose: Take ASAP. Skip if near next dose.

Storage

• Store below 30°C in original container

• Keep away from light/moisture

• Out of children’s reach

Always use under medical supervision. Dosage may vary by infection severity.  
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