Melixol Tablet - (500mcg + 10mg) contains a combination of two active ingredients: 

• Flupenthixol: 0.5 mg (500 micrograms) 
• Melitracen: 10 mg 

Indications:

Melixol is indicated for the treatment of: 

• Anxiety 
• Depression 
• Apathy 
• Psychogenic depression 
• Depressive neuroses 
• Masked depression 
• Psychosomatic affections accompanied by anxiety and apathy 
• Menopausal depressions 
• Dysphoria and depression in alcoholics and drug addicts 

Pharmacology:

• Flupenthixol: It is a neuroleptic drug with anxiolytic and antidepressant properties at low doses. Its antipsychotic effect is achieved by blocking dopamine D1 and D2 receptors in the brain. 
• Melitracen: It is a tricyclic antidepressant that works by blocking the re-uptake of both serotonin and noradrenaline in the central nervous system, thus alleviating symptoms of depression. 

Dosage and Administration:

The usual dosage for adults is 2 tablets per day, taken in the morning and at midday. In severe cases, the morning dose may be increased to 2 tablets. 

For elderly patients, the usual dose is 1 tablet in the morning. 

The maintenance dose is usually 1 tablet in the morning. 

In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase may be recommended. 

Important Considerations:

• Melixol may enhance the effects of alcohol, barbiturates, and other CNS depressants. 
• Simultaneous use with MAO inhibitors may cause hypertensive crises. It should not be given to patients who have received an MAO inhibitor within the last two weeks. 
• Neuroleptics and thymoleptics may reduce the antihypertensive effect of guanethidine and similar acting compounds. Thymoleptics may enhance the effects of adrenaline and noradrenaline. 
• It is contraindicated in the immediate recovery phase after myocardial infarction, defects in bundle-branch conduction, untreated narrow-angle glaucoma, acute alcohol, barbiturate, and opiate intoxications, and in excitable or overactive patients. 
• Common side effects may include transient restlessness and insomnia. 
• It should preferably not be given during pregnancy and lactation. 

Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication.