Migrex 200 mg Tablet

Based on the provided information, Migrex 200 mg Tablet, manufactured by Incepta Pharmaceuticals Ltd., contains Tolfenamic Acid BP 200 mg.  

Indications:

Migrex 200 is indicated for:

• Acute migraine attacks

Pharmacology:

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic activity. It inhibits the enzyme cyclooxygenase, leading to reduced production of prostaglandins, which are involved in pain and inflammation.

Dosage and Administration:

• The usual dose is 200 mg at the first sign of a migraine attack.
• If needed, another 200 mg dose may be taken 1-2 hours later.

Contraindications:

Migrex 200 is contraindicated in patients with:

• Known hypersensitivity to tolfenamic acid or other NSAIDs.
• Active peptic ulcer.  
• Severe hepatic or renal impairment.
• History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• Pregnancy (especially the third trimester).  

Precautions:

• Use with caution in patients with a history of peptic ulcer, bleeding disorders, cardiovascular disease, or hypertension.
• NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.  
• Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. 
• Tolfenamic acid should be taken with food to minimize gastrointestinal irritation.  

Side Effects:

Common side effects may include:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain)  
• Headache
• Dizziness  

Less common but potentially serious side effects can occur. It is important to report any unusual or severe symptoms to your doctor immediately.

Drug Interactions:

Tolfenamic acid can interact with various medications. Inform your doctor about all the medicines you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.Significant interactions can occur with anticoagulants, aspirin, other NSAIDs, antihypertensives, and diuretics.  

Pregnancy and Lactation:

Tolfenamic acid is generally not recommended during pregnancy, especially in the third trimester. It should be used with caution during breastfeeding. 

Storage:

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.