Indications

Minolac (Ketorolac Tromethamine) is a non-steroidal anti-inflammatory drug (NSAID) indicated for: 

• Tablets/Injection: Short-term management (up to 7 days) of moderate to severe acute post-operative pain requiring analgesia at the opioid level. 

• Ophthalmic Solution (Eye Drops): Relieving pain, inflammation, and light sensitivity after ocular surgery. It may also decrease eye inflammation or redness caused by seasonal allergies. 

   

Pharmacology

Ketorolac Tromethamine is a potent analgesic that acts by inhibiting the cyclooxygenase enzyme system , thereby inhibiting prostaglandin synthesis . This results in a strong analgesic (pain-relieving) effect with minimal anti-inflammatory action at analgesic doses.

Dosage & Administration

Note on Conversion: The total combined duration of parenteral (IV/IM) and oral treatment should not exceed 5 days . The combined daily dose on the day of conversion should not exceed 120 mg (or 60 mg for high-risk patients). 

Contraindications

Minolac is contraindicated in:

• Patients with hypersensitivity to Ketorolac or other .

• Children under 16 years of age.

• Use as a prophylactic analgesic before surgery.

Side Effects

Common side effects include nausea, vomiting, gastro-intestinal bleeding, peptic ulcer, headache, drowsiness, fatigue, anxiety, hypertension, and pulmonary edema.

Interaction

• Other or Aspirin: Increases the side effects of Minolac.

• Anti-coagulants (e.g., Warfarin): Enhances the anti-coagulant effect (risk of bleeding).

• Inhibitors: Increases the risk of renal impairment.

• Methotrexate: Enhances the toxicity of methotrexate.

Precautions & Warnings

• Use with caution in patients over 65 years of age.

• Caution is needed for patients with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction.

• Eye Drops: Patients showing corneal epithelial breakdown should immediately discontinue use and be closely monitored. Do not administer while wearing contact lenses.

Pregnancy & Lactation

Pregnancy category is C. It should be avoided unless the potential benefits outweigh the possible risks to the fetus. It is generally not recommended during lactation.

Therapeutic Class: Drugs used for Rheumatoid Arthritis, Non-Opioid Analgesics.

Storage: Keep in a dry place away from light and heat. Keep out of the reach of children.