Nalzin 10 Tablet contains 10 mg of Flunarizine Hydrochloride.

Brand Name: Nalzin

Generic Name: Flunarizine Hydrochloride

Manufacturer: Radiant Pharmaceuticals Ltd. (in Bangladesh)

Indications: Nalzin is indicated for:

• Prophylaxis of classic (with aura) or common (without aura) migraine.
• Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system).  
• Peripheral Vascular Disease (PVD).
• Motion sickness.
• Refractory epilepsy resistant to conventional antiepileptic therapy (as add-on therapy). 

Dosage and Administration: The dosage depends on the condition being treated and the patient's age and response. Some general guidelines:

• Migraine Prophylaxis:
  • Starting dose for patients less than 65 years: 10 mg at night.
  • Starting dose for patients older than 65 years: 5 mg daily at night.
  • If, during this treatment, depressive, extrapyramidal, or other unacceptable symptoms occur, administration should be discontinued.  
  • If no significant improvement is observed after 2 months of initial treatment, the patient should be considered a non-responder, and the drug should be discontinued.
  • Maintenance Treatment: If a patient responds satisfactorily and maintenance treatment is needed, the dose should be decreased to 5 days of treatment at the same daily dose with two successive medicine-free days every week.
  • Even if prophylactic maintenance treatment is successful and well-tolerated, it should be interrupted after 6 months and re-initiated only if the patient relapses.  
• Peripheral Vascular Disease: 10 mg twice daily, up to 30 mg per day if required.
• Vertigo & Motion Sickness: 10-20 mg daily for adults and 5 mg daily for children (weighing over 40 kg). 
• Epileptic Seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy.

Nalzin may lead to drowsiness and is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. Patients should be cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. Nalzin is not suitable for aborting a migraine attack. 

Side Effects: Common side effects may include:

• Drowsiness and/or fatigue.
• Weight gain and/or increased appetite.

The following adverse experiences have been reported during chronic treatment with Flunarizine:

• Depression (female patients with a history of depressive illness may be particularly at risk).
• Extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients are more at risk. 

Infrequently reported adverse reactions are:

• Heartburn
• Nausea
• Gastralgia (stomach pain)
• Insomnia
• Anxiety
• Galactorrhoea (abnormal milk flow)
• Dry mouth
• Muscle ache
• Skin rash

Precautions:

• Nalzin may lead to drowsiness, which is aggravated by alcohol or other CNS depressants.
• Caution should be taken while driving or operating machinery.
• This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly.  
• Use with caution in patients with a history of depression.

Contraindications: Nalzin is contraindicated in patients with:

• Hypersensitivity to Flunarizine.
• A history of depressive illness.
• Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.

Drug Interactions:

• Galactorrhoea has been reported in a few women on oral contraceptives within the first two months of Nalzin treatment.
• Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Nalzin by increasing its metabolism, potentially requiring an increase in the Nalzin dosage. 

Storage: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.