Napro-A Plus 375is a tablet containing a combination of two active ingredients: 

• Naproxen Sodium BP: 375 mg (a non-steroidal anti-inflammatory drug - NSAID)
• Esomeprazole BP:20 mg (a proton pump inhibitor - PPI) 

It is manufactured by ACME Laboratories Ltd. 

Indications: 

Napro-A Plus (Naproxen & Esomeprazole) is indicated for the treatment of the signs and symptoms of: 

• Osteoarthritis (OA) 
• Rheumatoid arthritis (RA)
• Ankylosing spondylitis (AS)
• Dysmenorrhoea (painful menstruation)

It is also used to decrease the risk of developing gastric ulcers in patients at risk for developing NSAID-associated gastric ulcers. 

Dosage and Administration: 

The usual recommended dose for adults is one tablet twice daily.

• The tablet must be swallowed whole with water and should not be split, chewed, crushed, or dissolved.
• Napro-A Plus should be taken at least 30 minutes before a meal.

Dosage for specific conditions:

• Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis: One tablet (either 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole) twice daily.
• Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older:
  • Weight greater than 50 kg: Same as adult dose.
  • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg esomeprazole.

Your doctor will determine the appropriate dosage and duration of treatment based on your condition and response.

Important Notes:

• Napro-A Plus is not recommended for the initial treatment of acute pain because the absorption of naproxen is delayed compared to other naproxen-containing products. 
• The lowest effective dose should be used for the shortest possible duration consistent with individual patient treatment goals.
• The combination of Naproxen and Esomeprazole with other NSAIDs, including cyclooxygenase-2 selective inhibitors, should be avoided due to the cumulative risk of serious NSAID-related adverse events.

Please consult your doctor for specific instructions and guidance regarding the use of Napro-A Plus 375.