Presentation:Each extended-release tablet contains 500 mg of metformin hydrochloride.  

Indications:Nobesit XR is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight patients, when diet and exercise alonedo not result in adequate glycemiccontrol.In adults, it may be used as monotherapy or in combination with other oral antidiabetic agents or with insulin.  

Dosage and Administration: The dosage of Nobesit XR should be individualized based on both effectiveness and tolerability, while not exceeding the maximum recommended daily dose.

• The usual starting dose of Metformin XR is 500 mg once daily with the evening meal.  
• Dose should be increased in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal,or alternatively increased to 1000 mg twice daily taken with meals.
• Patients receiving Metformin immediate-release tablets may be switched to Metformin extended-release tablets up to a maximum recommended dailydose.
• Nobesit XR tablets should be swallowed whole and never crushed, cut, or chewed.
• It should be taken with food to help reduce gastrointestinal side effects.

Side Effects: Common side effects may include gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These side effects occurmost frequently during initiationof therapy and usually resolve spontaneously. A slow increase of the dose may improve gastrointestinal tolerability. Taste disturbance is also a common side effect.

Less common but more serious side effects can include lactic acidosis, a rare but potentially life-threatening condition.Symptoms of lactic acidosis may include deep and rapid breathing, persistent nausea, vomiting, and stomach pain.If you experience these symptoms, seek immediate medical attention. Long-term use of metformin may lead to a decrease in vitamin B12 absorption.  

Precautions:Nobesit XR is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute metabolic acidosis, including diabetic ketoacidosis, and known hypersensitivity to metformin or any of the excipients.It is not recommended for use in patients with type 1 diabetes mellitus. Assess renal function before initiation and monitor periodically. Avoid excessive alcohol intake. Metformin should be temporarily discontinued in patients undergoing radiologic studies with intravascular administration of iodinated contrast materials or any surgical procedures necessitating restricted intakeof food and fluids.Caution should be exercised in patients with conditions that may increase the risk of lactic acidosis (e.g., dehydration, severe infection, shock).

Storage:Store below 30°C in a dry place, protected from light and moisture.Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.