Indications

• Symptomatic relief for:

  • Allergic rhinoconjunctivitis (seasonal and perennial)

  • Urticaria (hives)

  • Hay fever symptoms (sneezing, runny/blocked/itchy nose, watery/red eyes)

Dosage & Administration

Note: Take on an empty stomach with water for optimal absorption. Always follow a registered physician's advice.

• Adults & Adolescents (12+ years): 20 mg (1 tablet) once daily.

• Children (6–11 years): 10 mg (1 mouth-dissolving tablet) once daily. Place directly in the mouth to disperse in saliva, or mix in a teaspoon of water.

• Children (2–11 years): 4 ml once daily.

• Children under 2 years: Not recommended (safety not established).

• Missed Dose: Take the next scheduled dose as planned. Do not take double or extra doses.

Key Pharmacological Highlights

• Mechanism: A potent, long-acting $H_1$ receptor antagonist (3× higher affinity than cetirizine, 5× higher than fexofenadine).

• Metabolism & Excretion: Does not require liver metabolism; excreted via feces (~66.35%) and urine (~28.31%).

Side Effects & Warnings

• Common Side Effects: Headache, dizziness, drowsiness/somnolence, and fatigue (rates are comparable to placebo).

• Precautions: While generally non-sedating and safe for driving, rare cases of drowsiness can occur.

• Special Populations:

  • Renal/Liver Impairment & Elderly: No dosage adjustment needed.

  • Pregnancy & Breastfeeding: Best avoided during pregnancy as a precaution; consult a physician to weigh benefits while breastfeeding.

Interactions & Overdose

• Drug Interactions: Ketoconazole, erythromycin, cyclosporine, or diltiazem may increase Obila levels without altering its overall safety. Does not significantly interact with alcohol or lorazepam.

• Overdose: Doses up to 10–11 times the recommended limit primarily caused increased dizziness, headache, and nausea without severe heart or CNS complications.

Storage

Store below 30°C, protected from light and moisture. Keep out of reach of children.