Omidon 60ml Suspension - (5mg/5ml) contains Domperidoneas its active ingredient.It is available in a 60ml bottle.  

Indications:

Omidon (Domperidone) is used to treat:

• Dyspeptic symptom complex, often associated with delayed gastric emptying, gastro-oesophageal reflux and oesophagitis, including:
  • Epigastric fullness 
  • Abdominal distension  
  • Upper abdominal pain 
  • Belching 
  • Flatulence 
  • Early satiety 
  • Nausea and vomiting 
  • Heartburn with or without regurgitation  
• Acute nausea and vomitingof functional, organic, infectious, dietetic origin, or induced by radiotherapy, drug therapy, or migraine.  
• Nausea and vomiting associated with Parkinson's disease (induced by dopamine agonists).
• Non-ulcer dyspepsia.  
• To speed up barium transit in radiological studies.  

Pharmacology:

Domperidone is a dopamine receptor antagonist that works primarily in the Chemoreceptor Trigger Zone (CTZ) and the stomach. By blocking dopamine receptors, it helps to:

• Restore normal motility and tone in the upper gastrointestinal tract.  
• Facilitate gastric emptying.  
• Enhance antral and duodenal peristalsis.  
• Regulate pylorus contraction.
• Increase oesophageal peristalsis and lower oesophageal sphincter pressure, thus preventing regurgitation.  

Domperidone has limited penetration into the brain, minimizing psychotropic and neurological side effects.  

Dosage and Administration:

• Omidon Suspension should be taken 15-30 minutes before mealsand, if needed, before bedtime.  
• Adults: The usual dose is 10-20 mg (1-2 teaspoonfuls = 10-20 ml)every 6-8 hours, with a maximum daily dose of 80 mg.  
• Children: The dose is 0.2-0.4 mg/kgbody weight (2-4 ml suspension per 10 kg body weight) every 6-8 hours daily.  
• For acute nausea and vomiting, the maximum treatment duration is 12 weeks.  

Side Effects:

Side effects are generally rare and mild. They may include:

• Transient intestinal cramps
• Increased prolactin levels (possibly leading to galactorrhoea and gynaecomastia in rare cases)  
• Dry mouth  
• Thirst  
• Headache  
• Nervousness  
• Drowsiness
• Diarrhoea
• Skin rash and itching  

Extrapyramidal effects are rare, especially in adults, and usually resolve when treatment is stopped.  

Precautions:

• Use with caution in childrendue to a potential increased risk of extrapyramidal reactions, especially in very young children.  
• Use with caution in patients with hepatic impairmentas domperidone is metabolized in the liver.  
• Caution is advised in patients with renal impairment; the dosing interval may need adjustment in severe cases.  
• Use with caution in the elderly and in patients with a known risk of cardiac arrhythmiasor prolonged cardiac conduction intervals.  

Contraindications:

Omidon is contraindicated in patients with:

• Known hypersensitivity to domperidone.  
• Neonates.
• Conditions where gastrointestinal stimulation might be dangerous (e.g., haemorrhage, obstruction, perforation).
• Prolactin-releasing pituitary tumour (prolactinoma).

Pregnancy & Lactation:

• Use during pregnancy is not recommended unless the potential benefits outweigh the risks.
• Domperidone may help with post-natal lactation.It is secreted in breast milk in very small amounts not considered harmful.  

Drug Interactions:

• May reduce the hypoprolactinaemic effect of bromocriptine.
• The effect on GI function may be antagonized by anticholinergics and opioid analgesics.
• Caution should be exercised with MAO inhibitors.
• Antacids and antisecretory drugs may reduce the oral bioavailability of domperidone and should not be taken concurrently.  

Storage:

Store below 30°C, protected from light. Keep out of the reach of children.

Therapeutic Class:

Motility Stimulants, Prokinetic drugs.  

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.