Ondason Tablet - (8mg)

Generic Name: Ondansetron Hydrochloride

Manufacturer: Drug International Ltd.

Strength: Available in 8 mg tablets.

Indications:

• Nausea and Vomiting: Prevention of nausea and vomiting associated with:
  • Chemotherapy-induced nausea and vomiting (CINV)
  • Radiotherapy-induced nausea and vomiting (RINV)
  • Postoperative nausea and vomiting (PONV)

Dosage and Administration:

• Dosage should be determined by a physician based on the emetogenic potential of the treatment.
• Chemotherapy-induced Nausea and Vomiting (CINV):
  • Highly emetogenic chemotherapy: 24 mg orally as a single dose 30 minutes before the start of chemotherapy.
  • Moderately emetogenic chemotherapy: 8 mg orally 30 minutes before the start of chemotherapy, followed by 8 mg orally 8 hours after the first dose. Then, 8 mg orally twice a day (every 12 hours) for 1-2 days after chemotherapy.
• Radiotherapy-induced Nausea and Vomiting (RINV): 8 mg orally 1-2 hours before each fraction of radiotherapy.
• Postoperative Nausea and Vomiting (PONV): 16 mg orally as a single dose 1 hour before anesthesia.
• For children, dosage is based on weight or body surface area as determined by the physician.
• Ondason tablets can be taken with or without food.

Contraindications:

• Hypersensitivity to ondansetron or any of the excipients.
• Concomitant use with apomorphine.

Side Effects:

• Common: Headache, constipation.
• Less Common: Dizziness, fatigue, diarrhea, abdominal pain, dry mouth.
• Rare: Hypersensitivity reactions (e.g., rash, urticaria, angioedema), transient ECG changes including QT interval prolongation, seizures.

Precautions:

• Use with caution in patients with a history of cardiac problems, especially QT prolongation.
• Monitor ECG in patients with electrolyte abnormalities or those taking other medications that prolong the QT interval.
• Use with caution in patients with hepatic impairment.
• May mask progressive ileus and/or gastric distension following abdominal surgery.
• Serotonin syndrome has been reported with 5-HT3 receptor antagonists, particularly when used concomitantly with other serotonergic drugs.

Use in Pregnancy & Lactation:

• Pregnancy: Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Lactation: Ondansetron is excreted in breast milk. Caution should be exercised when administering ondansetron to a breastfeeding woman.

Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.