Indications

Optimox (Moxifloxacin) ophthalmic solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible microorganisms. These include a variety of Gram-positive, Gram-negative, and other microorganisms, such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Chlamydia trachomatis. It is also used as an intraocular injection to prevent postoperative bacterial endophthalmitis.

Pharmacology

Moxifloxacin is an antibiotic that inhibits two essential bacterial enzymes: topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is critical for DNA replication, transcription, and repair, while topoisomerase IV plays a key role in bacterial cell division. By inhibiting these enzymes, Moxifloxacin disrupts the bacterial DNA and has an antimicrobial action.

Dosage & Administration

• Eye Drops: One drop in the affected eye three times a day for 7 days.
• Eye Ointment: Apply a thin, even layer to the affected eye three times a day for the first two days, then twice a day for the next five days.
• Intraocular Injection: A dose of 0.2-0.4 ml can be administered prior to ocular surgery. The final dose is determined by the doctor.

Interaction

Drug-drug interaction studies have not been conducted with this ophthalmic solution. However, in vitro studies suggest that Moxifloxacin is unlikely to alter the pharmacokinetics of other drugs metabolized by CYP450 enzymes.

Contraindications

This product is contraindicated in patients with a history of hypersensitivity to Moxifloxacin, other quinolones, or any of the components in the medication.

Side Effects

The most common ocular side effects (1-6% of patients) include conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, pain, redness, itching, subconjunctival hemorrhage, and tearing. Non-ocular side effects (1-4%) include fever, increased cough, infection, otitis media, pharyngitis, rash, and rhinitis.

Pregnancy & Lactation

• Pregnancy: There are no adequate and well-controlled studies in pregnant women. The medication should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Lactation: It is presumed to be excreted in human milk, so caution should be exercised when administering to a nursing mother.

Precautions & Warnings

• Superinfection: Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi. If a superinfection occurs, discontinue use and institute alternative therapy.
• Contact Lenses: Patients with bacterial conjunctivitis should be advised not to wear contact lenses.

Therapeutic Class

Optimox is classified as an ophthalmic antibacterial drug.

Storage Conditions

Store below 25°C. Do not freeze. Store in a cool, dry place, protected from light. Keep out of the reach of children. Do not touch the dropper tip to any surface to avoid contamination. Do not use after one month of first opening.