Ornova 10 

Presentation: Each film-coated tablet contains Vonoprazan Fumarate INN equivalent to Vonoprazan 10 mg. Ornova 10 is a product of ACI Limited in Bangladesh and is usually available in blister packs.  

Indications:Ornova (Vonoprazan) is a potassium-competitive acid blocker (P-CAB) indicated for:  

• Treatment of gastric ulcer.  
• Treatment of duodenal ulcer.  
• Treatment of reflux esophagitis (erosive esophagitis).  
• Maintenance treatment of reflux esophagitis (erosive esophagitis) in patients with repeat recurrence and relapse.  
• Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration.  
• Prevention of recurrence of gastric ulcer or duodenal ulcer during low-dose aspirin administration.  
• Adjunct to Helicobacter pylorieradication in the following conditions: gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer,or Helicobacter pylorigastritis.  

Dosage and Administration:Ornova 10 tablets should be taken orally without regard to food or timing of food.  

• Prevention of recurrence of gastric or duodenal ulcer during NSAIDs administration:The dose is 10 mg once daily.  
• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration:The dose is 10 mg once daily.  
• Maintenance treatment of reflux esophagitis: The usual dose is 10 mg once daily, which may be increased to 20 mg once daily if efficacy is inadequate.
• For other indications, the usual starting dose is 20 mg once daily. Please consult your physician for the appropriate dose and duration based on your specific condition.

Side Effects: The most common side effects reported with Vonoprazan include:

• Diarrhoea
• Constipation  
• Drug hypersensitivity (including anaphylactic shock)  
• Drug eruption  
• Urticaria  
• Hepatotoxicity  
• Jaundice  
• Rash  
• Nausea  
• Abdominal distension  
• Increased liver enzymes (gamma-glutamyl transferase, AST, ALT)
• Abnormal liver function test

Precautions:Ornova (Vonoprazan) is contraindicated in patients with hypersensitivity to Vonoprazan or any excipients in the product, and in patients receiving atazanavir sulphate, nelfinavir, or rilpivirine hydrochloride.  

Caution should be exercised in patients with liver function abnormalities or signs/symptoms suggestive of liver dysfunction, and in patients with renal disorders.Vonoprazan should be administered with care in patients taking drugs for which absorption is dependent on acidic intragastric pH.Gastric malignancy should be excluded before starting treatment.

Use in Pregnancy and Lactation: Ornova should only be used during pregnancy if the expected therapeutic benefit outweighs the possible risk. It is advisable to avoid administration to nursing mothers; if deemed necessary, breastfeeding should be discontinued during treatment.

Storage:Store below 30°C, in a cool and dry place, protected from light.Keep out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.