PCab 10 

Presentation: PCab 10 is presented as a tablet containing 10 mg of Vonoprazan.

Indications: PCab is indicated for:

• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration.  
• Prevention of recurrence of gastric or duodenal ulcer duringNSAID administration.  
• Maintenance therapy of reflux esophagitis showing recurrence and recrudescence (when the efficacy of a 20mg dose was adequate initially).
• Healing of erosive esophagitis.
• Relief of heartburn associated with erosive esophagitis.
• In combination with antibiotics for the eradication of Helicobacter pylori.
• Relief of heartburn associated with non-erosive Gastroesophageal Reflux Disease (GERD).

Dosage and Administration:

• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration:The usual adult dose is one tablet of 10mg administered orally once daily.  
• Prevention of recurrence of gastric or duodenal ulcer during non-steroidal anti-inflammatory drug (NSAID) administration:The usual adultdose is one tablet of 10mg administered orally once daily.
• Maintenance therapy of reflux esophagitis showing recurrence and recrudescence: The usual dose is 10 mg once daily. However, when efficacy is inadequate, the dosage may be increased up to 20 mg once daily.
• Healing of erosive esophagitis: The usual adult dose is 20 mg once daily for 4 weeks. If healing is not complete, an additional 4 weeks of treatment may be considered. For maintenance therapy after healing, the dose is 10 mg once daily.
• Relief of heartburn associated with erosive esophagitis: 20 mg once daily for up to 6 months.
• Eradication of H. pylori: PCab is used in combination with amoxicillin and clarithromycin, or with amoxicillin alone, typically at a dose of 20 mg twice daily for 7 to 14 days. The specific regimen will be determined by your doctor.
• Relief of heartburn associated with non-erosive GERD: 10 mg once daily for up to 4 weeks.
• Vonoprazan can be taken without regard to food or timing of food.

Side Effects: The following side effects have been reported with the use of PCab (containing Vonoprazan):

• Diarrhea  
• Constipation  
• Drug hypersensitivity (including anaphylactic shock)  
• Drug eruption  
• Urticaria (hives)  
• Hepatotoxicity (liver damage)  
• Jaundice (yellowing of the skin and eyes)
• Rash
• Nausea
• Abdominal distension
• Increased liver enzymes (Gamma-glutamyl transferase, AST, ALT)
• Abnormal liver function test
• Stomach bloating
• Stomach pain
• Indigestion
• Urinary tract infection
• Cold-like symptoms
• Temporary changes in taste
• Vaginal yeast infections

Precautions:

• PCab is contraindicated in patients with hypersensitivity to Vonoprazan or to any excipient of the product.
• PCab is contraindicated in patients receiving atazanavir sulphate, nelfinavir, or rilpivirine hydrochloride.  
• At the treatment, the course of the disease shouldbe closely observed and the minimum therapeutic necessity should be considered.
• Vonoprazan should be used in pregnant women or women having the possibility of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk.  
• It is advisable to avoid the administration of Vonoprazan to nursing mothers. However, when the administration is indispensable, nursing should be discontinued.  
• Caution is advised when consuming alcohol with Vonoprazan.
• Monitor for potential interactions with other medications, including those metabolized by CYP3A4 and CYP2C19. Vonoprazan may affect the absorption of other drugs due to its potent acid-suppressing effect.
• Long-term use may increase the risk of fundic gland polyps.
• Long-term use may lead to vitamin B12 deficiency.
• Monitor for symptoms of low magnesium levels, especially with prolonged use.
• Discontinue if severe skin reactions occur.
• Use with caution in patients with severe renal or hepatic impairment.

Storage: Store below 30°C, in a cool and dry place, away from light. Keep all medicine out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.