Permin (Permethrin) Cream: A Parasiticidal Preparation

Permin cream contains Permethrin, a topical scabicidal agent. It is indicated for the treatment of infestations with scabies (Sarcoptes Scabiei) and crab lice (Pediculosis). Scabies is highly contagious, and if one person in a family is infected, all family members should be treated together to prevent re-infestation. Permin cream belongs to the therapeutic class of parasiticidal preparations.

How Permin Cream Works (Pharmacology)

Permethrin works by disrupting the nervous system of the parasites:

• Disrupts Sodium Channels: It acts on the nerve cell membranes of the scabies mites and lice to disrupt the flow of sodium ions.
• Causes Paralysis: This disruption of the sodium channel current leads to delayed repolarization and paralysis of the pests, ultimately causing their death.
• Minimal Systemic Absorption: When applied topically, less than 0.5% of the permethrin is absorbed into the body. The absorbed amount is rapidly metabolized and excreted, primarily in the urine.

Key Indications & Benefits

Permin cream is indicated for the treatment of:

• Scabies infestations.
• Crab lice infestations.

Dosage & Administration

Permin cream is applied topically to the skin. The recommended dosage and application method vary by age. Always consult a registered physician for specific dosage instructions.

• Before application: The skin should be clean, cool, and dry.
• Adults and children over 2 years: Apply the cream to the entire body from the neck down, including between the fingers and toes, and under the nails.
• Babies under 2 years: Apply to the face, neck, ears, and scalp as well, avoiding the areas immediately around the eyes and mouth.
• Leave on for at least 8 hours: The cream should be left on for a minimum of 8 hours before being washed off. If any area is washed during this time, reapply the cream to that spot.
• Re-treatment: If necessary, a second application can be done after 7 days, as advised by a doctor.

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before using Permin cream.

Contraindications:

• Known hypersensitivity to permethrin, other pyrethroids, or any component of the cream.

Side Effects:

• Common: Skin discomfort, described as burning, stinging, or tingling.
• Other temporary signs of irritation: Redness (erythema), swelling (edema), rash, and itching (pruritus).

Pregnancy & Lactation:

• Pregnancy: It should only be used during pregnancy if medically advised, as there are no specific studies in pregnant women.
• Lactation: It is unknown if permethrin is excreted in human milk. Therefore, it should not be used by nursing mothers.

Precautions & Warnings:

• Exacerbation of Symptoms: Scabies symptoms like itching and redness may temporarily worsen after treatment with Permin.
• Eye Contact: Avoid contact with the eyes. If the cream gets in the eyes, flush immediately with water.
• Gloves: Nursing staff who apply the cream to patients routinely should wear gloves to prevent potential hand irritation.
• Corticosteroids: Treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with Permin, as it may reduce the immune response and worsen the scabies.

Storage Conditions

Store in a cool, dry place, away from light and out of the reach of children.