Proliv IV 100ml Infusion

Presentation: A sterile aqueous solution for intravenous infusion. The exact composition may vary slightly depending on the specific formulation (e.g., Proliv 5% or Proliv-Plus 7%+10%). Generally, it contains a mixture of essential and non-essential amino acids, and may also include D-Sorbitol and/or Glucose, along with electrolytes in some formulations. Available in 100ml PVC (medical grade) bags, manufactured by Orion Infusion Ltd. in Bangladesh. The solution is usually clear and colorless to light yellow.

Indications: Proliv IV infusion is indicated as a source of amino acids for protein synthesis in patients requiring parenteral nutrition, especially those with basic amino acid requirements. It can be beneficial for individuals needing intravenous feeding due to:

• Inability to absorb nutrients orally (e.g., pre- and post-surgery).
• Increased protein requirements (e.g., due to burns, sepsis, trauma).
• Faster recovery in conditions like surgery, burns, renal insufficiency, hepatic insufficiency, and cancer treatment.
• As a source of fluids, electrolytes, and carbohydrates (depending on the specific formulation).

Dosage and Administration: The dosage and rate of infusion depend on the patient's clinical condition, nutritional status, degree of metabolic stress, body weight, and individual needs. It should be administered intravenously by a healthcare professional.

• Adults: The nitrogen requirement for maintenance of body protein mass ranges from 0.10-0.25 g nitrogen/kg/day, corresponding to approximately 11-35 ml/kg/day of amino acid solution (depending on the concentration). The infusion rate is usually slow, around 30-60 drops per minute.
• Children and Infants: The recommended infusion rate is generally 28-35 ml/kg body weight per day, with a gradual increase during the first week.

The solution should be visually inspected for particulate matter and discoloration before use.

Side Effects: Proliv IV infusion is generally well-tolerated. However, some side effects may occur:

• Nausea (rare)
• Vomiting, flushing, and sweating (if infused at a rate exceeding the recommended maximum)
• Transient elevations in liver tests
• Hypersensitivity reactions
• Thrombophlebitis (inflammation of a vein) at the infusion site, especially with peripheral administration of hypertonic solutions. Simultaneous infusion of a 10% fat emulsion may reduce this risk.
• Increased urinary excretion of trace elements like copper and zinc during long-term infusion.
• Hyperphenylalaninemia in critically ill, premature infants.

Precautions:

• Contraindicated in patients with inborn errors of amino acid metabolism, severe hepatic dysfunction, and severe uremia without dialysis facilities.
• Formulations containing glucose are contraindicated in hyperosmolar nonketotic diabetic coma.
• Use with caution in patients with diabetes mellitus, severe heart failure, or renal impairment, especially with fluid restrictions or oliguria/anuria.
• Monitor serum potassium and blood glucose levels, especially with rapid or high-volume infusions.
• In severely malnourished patients, refeeding carbohydrates may trigger thiamine deficiency.
• Increased risk of metabolic acidosis may occur with rapid infusion in neonates, especially premature infants.
• Use with caution during pregnancy and breastfeeding; consult a healthcare professional.

Storage: Store between 15°C to 25°C, protected from direct sunlight. Avoid freezing. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.