Quiet XR 50

Presentation: Each extended-release tablet contains Quetiapine Fumarate equivalent to Quetiapine 50 mg. 

Indications: Quiet XR (Quetiapine Extended-Release) is indicated for the treatment of schizophrenia, bipolar disorder (including manic, depressive, and mixed episodes), and as adjunctive therapy for major depressive disorder. The extended-release formulation is intended for once-daily dosing.

Dosage and Administration: Dosage should be individualized and determined by a healthcare professional based on the specific condition being treated and the patient's response. Quiet XR tablets should be swallowed whole and not chewed, crushed, or divided. It is recommended to take Quiet XR once daily, preferably in the evening, with or without food.

• Schizophrenia: The usual starting dose is 300 mg on Day 1, 600 mg on Day 2, and may be adjusted thereafter to a target range of 400 mg to 800 mg per day.
• Bipolar Disorder (Manic Episodes): The starting dose is 300 mg on Day 1, 600 mg on Day 2
• Bipolar Disorder (Depressive Episodes): The starting dose is 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4. The recommended dose range is 300 mg to 600 mg once daily.
• Adjunctive Therapy for Major Depressive Disorder: The starting dose is 50 mg once daily at bedtime, with gradual increases to a target dose of 150 mg to 300 mg once daily.

Side Effects: Common adverse reactions may include somnolence, dizziness, dry mouth, increased appetite, weight gain, and elevated triglyceride levels. Less common side effects may include orthostatic hypotension, tachycardia, constipation, and blurred vision.

Precautions: Quiet XR is contraindicated in patients with known hypersensitivity to quetiapine or any of its components and should not be used concomitantly with strong CYP3A4 inducers. Caution should be exercised in patients with a history of cardiovascular disease, cerebrovascular disease, conditions predisposing to hypotension, hepatic impairment, or seizures. Monitor for tardive dyskinesia and neuroleptic malignant syndrome. May increase the risk of suicidal thoughts and behavior, especially in young adults.

Storage: Store below 30°C, protected from light and moisture. Keep out of reach of children.

Note: This information is a general overview. Always consult a healthcare professional for specific prescribing information and guidance.