Rabepes 20 

Presentation: Each enteric-coated tablet contains Rabeprazole Sodium INN 20 mg.

Indications: Rabepes (Rabeprazole) is a proton pump inhibitor (PPI) indicated for the treatment of acid-related disorders, including:

• Active duodenal ulcer  
• Active benign gastric ulcer  
• Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
• Long-term management of GERD (GERD Maintenance)
• Symptomatic treatment of moderate to very severe GERD  
• Zollinger-Ellison Syndrome  
• In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease.  

Dosage and Administration: Rabepes 20 tablets should be swallowed whole and taken once daily in the morning, before eating.  

• Active Duodenal Ulcer and Active Benign Gastric Ulcer:   The recommended oral dose is 20 mg once daily. Most patients with duodenal ulcer heal within 4 weeks, and most with gastric ulcer heal within 6 weeks. Some patients may require an additional 4-6 weeks of therapy.
• Erosive or Ulcerative GERD: The recommended oral dose is 20 mg once daily for 4 to 8 weeks. An additional 8-week course may be considered if healing is not complete.
• GERD Long-term Management (GERD Maintenance): The maintenance dose is 20 mg or 10 mg once daily, depending on patient response.  
• Symptomatic GERD: 10 mg once daily in patients without oesophagitis. If symptoms do not improve within 4 weeks, further investigation is needed. Once symptoms resolve, an on-demand regimen of 10 mg once daily can be used.  
• Zollinger-Ellison Syndrome: The recommended starting dose is 60 mg once daily, adjusted up to 120 mg/day based on individual needs. Doses over 100 mg may be divided into two daily doses.
• H. pylori Eradication: The recommended regimen is Rabeprazole 20 mg twice daily, Clarithromycin 500 mg twice daily, and Amoxicillin 1 g twice daily for 7 days.

Side Effects: Common side effects may include headache, diarrhoea, abdominal pain, nausea, vomiting, constipation, and dry mouth. Less common side effects can include dizziness, insomnia, and skin rash. Long-term use may increase the risk of bone fractures, low magnesium levels, and vitamin B12 deficiency in some individuals.

Precautions: Rabepes (Rabeprazole) is contraindicated in patients with known hypersensitivity to rabeprazole, other PPIs, or any excipients. Gastric malignancy should be excluded before initiating therapy. Caution should be exercised in patients with severe hepatic impairment.

Use in Pregnancy and Lactation: Rabeprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. It is not known if rabeprazole is excreted in human milk. Caution should be exercised when administering to breastfeeding women.

Storage: Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.