Rehanzil

Presentation: Each tablet contains relugolix 40 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg. 

Indications:Rehanzil is indicated for the management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids) in premenopausal women.  

Dosageand Administration: The recommended dosage is one tablet taken orally once daily at approximately the same time, with or without food. Rehanzil should be started as early as possible after the onset of menses but no later than seven days after menses has started. Prior to initiation, pregnancy should be excluded, and hormonal contraceptives should be discontinued. The recommended total duration of treatment is 24 months. In case of a missed dose, it should be taken as soon as possible on the same day, and regular dosing should resume the next day at the usual time.

Side Effects: The most common adverse reactions (incidence ≥ 3%) are hot flush, hyperhidrosis or night sweats, uterine bleeding, alopecia, and decreased libido.  

Precautions:   Caution should be taken in patients with thromboembolic disorders and vascular events, bone loss, depression, mood disorders and suicidal ideation, hepatic impairment and transaminase elevations, elevated blood pressure,and changes in menstrual bleeding patterns. Rehanzil is contraindicated in pregnancy and should be discontinued if pregnancy occurs. It is also contraindicated in patients with a high risk of arterial, venous thrombotic, or thromboembolic disorder, known osteoporosis, current or history of breast cancer or other hormone-sensitive malignancies, known hepatic impairment or disease,and undiagnosed abnormal uterine bleeding. Effective non-hormonal contraception should be used during treatment.

Storage: Store in a cool and dry place, protected from light. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.