Renolina M 500 

Presentation: Each tablet contains Linagliptin 2.5 mg and Metformin Hydrochloride 500 mg. Available in strips.

Indications: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both linagliptin and metformin is appropriate.

Dosage and Administration: The dosage should be individualized based on effectiveness and tolerability, not exceeding the maximum recommended daily dose of linagliptin 5 mg and metformin hydrochloride 2000 mg. The usual starting dose in patients not currently treated with metformin is one tablet twice daily with meals. In patients already on metformin, start with one tablet of Renolina M 500 twice daily, providing the same daily dose of metformin. Swallow whole with water; do not crush or chew. Dose escalation should be gradual to reduce gastrointestinal side effects associated with metformin.

Side Effects: Common side effects may include diarrhea, nausea, vomiting, and headache. Hypoglycemia may occur when used in combination with insulin or sulfonylureas.

Precautions: Contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute metabolic acidosis, diabetic ketoacidosis, and known hypersensitivity to linagliptin or metformin. Use with caution in patients with moderate renal impairment, liver disease, and a history of pancreatitis. Avoid excessive alcohol intake.

Storage: Store in a dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.