Sitazid M 50/1000 (Tablet)

Presentation: Each tablet contains Sitagliptin Phosphate Monohydrate INN equivalent to Sitagliptin 50 mg and Metformin Hydrochloride BP 1000 mg. Available in strips.

Indications: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.

Dosage and Administration: The usual starting dose is one tablet twice daily with meals. Dosage should be individualized based on the patient's current regimen, glycemic control, and tolerability, not exceeding the maximum recommended daily dose of sitagliptin 100 mg and metformin 2000 mg. In patients not currently treated with metformin, the starting dose is usually one tablet twice daily with meals, with gradual dose escalation recommended to reduce gastrointestinal side effects associated with metformin. In patients already on metformin, the starting dose should provide sitagliptin dosed as 50 mg twice daily and the dose of metformin already being taken. Swallow whole with water; do not crush or chew.

Side Effects: Common side effects may include diarrhea, nausea, vomiting, upset stomach, and headache. Hypoglycemia may occur when used in combination with insulin or sulfonylureas. Upper respiratory tract infection and sore throat have also been reported.

Precautions: Contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and a history of serious hypersensitivity reaction to sitagliptin or metformin. Use with caution in patients with moderate renal impairment, history of pancreatitis, and heart failure. Temporary discontinuation may be required for surgical procedures or radiological examinations involving iodinated contrast media. Avoid excessive alcohol intake.

Storage: Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.