Sizonil 1 Tablet

Presentation: Each film-coated tablet contains Trifluoperazine Hydrochloride USP equivalent to Trifluoperazine 1 mg.

Indications: Sizonil is a typical antipsychotic medication used for:

• Management of psychotic disorders such as acute or chronic schizophrenia (catatonic, hebephrenic, and paranoid types).
• Psychosis due to organic brain damage or toxic causes.
• Manic phase of manic-depressive illness.
• Short-term management of severe anxiety states, including anxiety associated with somatic conditions or depressive symptoms secondary to anxiety, and agitation.
• Symptomatic treatment of nausea and vomiting.

Dosage and Administration: The dosage varies depending on the condition being treated and the patient's response. It is administered orally.

• Schizophrenia and other psychoses:
  • Adults and children over 12 years: The recommended starting dose is 2-5 mg twice daily, increased by 5 mg daily after one week, then at intervals of 3 days according to response. Usually, dosages do not need to exceed 15 mg daily.
  • Children (6-12 years): Dosage should be adjusted to the child's weight and symptom severity. The starting dose is 1 mg twice daily. Dosage may be increased gradually until symptoms are controlled or side effects become troublesome, usually not exceeding 15 mg daily.
  • Elderly: Reduce the initial dose by at least half.
• Short-term management of severe anxiety:
  • Adults and children over 12 years: 1-2 mg twice daily, increased if necessary to a maximum of 6 mg daily.
  • Children (3-5 years): 1 mg daily.
  • Children (6-12 years): Up to 4 mg daily in divided doses.
  • Elderly: Reduce the initial dose by at least half.
• Antiemetic:
  • Adults: 2-4 mg daily in divided doses, maximum 6 mg daily.
  • Children (3-5 years): Up to 1 mg daily.
  • Children (6-12 years): Up to 4 mg daily.

Take this medicine as directed by your doctor, usually with or without food. Taking it at the same time each day helps maintain a consistent level in the body. Swallow the tablet whole and do not chew or crush it.

Side Effects: Common side effects may include:

• Sleepiness
• Dizziness
• Dry mouth
• Blurred vision
• Muscle weakness
• Restlessness
• Skin reactions (rash)
• Insomnia (difficulty sleeping)
• Absence of menstrual periods
• Fatigue
• Decreased appetite
• Extrapyramidal symptoms (muscle stiffness, dystonia, parkinsonism, tardive dyskinesia, akathisia)
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Weight gain
• Increased prolactin level in the blood
• Urinary retention
• Constipation
• Tremor

Less common but potentially serious side effects can occur. Report any unusual symptoms to your doctor immediately.

Precautions:

• Use with caution in elderly patients, and the initial dosage should be reduced.
• Exercise caution in patients with cardiovascular disease, including arrhythmias, and angina pectoris.
• Care should be taken in patients with epilepsy or a history of seizures, angle-closure glaucoma, and exposure to extreme temperatures.
• Avoid alcohol consumption as it may increase drowsiness.
• Use caution while driving or operating machinery as Sizonil may cause dizziness and drowsiness.
• Inform your doctor if you are pregnant or breastfeeding.

Contraindications: Sizonil is contraindicated in patients with:

• Comatose states.
• Pre-existing CNS depression.
• Bone marrow depression or blood dyscrasias.
• Known liver damage.
• Hypersensitivity to trifluoperazine or related compounds.

Drug Interactions: Sizonil may interact with several medications, including:

• Alcohol, hypnotics, and strong analgesics (may increase CNS depression).
• Guanethidine and related antihypertensive compounds (may counteract their effects).
• Oral anticoagulants (may diminish their effect).
• Propranolol (may increase plasma levels of both drugs).

Inform your doctor about all the medications you are currently taking.

Storage: Store below 30°C, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.