Syncapone 50 Tablet

Syncapone 50 is a prescription medication used to treat Parkinson's disease. It helps to reduce excessive shaking and slow down body movements.

• Active Ingredients: Levodopa 50mg, Carbidopa 12.5mg, and Entacapone 200mg

• Use: Treatment of adult patients with Parkinson's disease and end-of-dose motor fluctuations not stabilized on levodopa/dopa decarboxylase (DDC) inhibitor treatment.

• How it works:

  • Levodopa is converted to dopamine in the brain, increasing the amount of this chemical messenger that controls movement.

  • Carbidopa prevents the breakdown of Levodopa, allowing more of it to reach the brain.

  • Entacapone helps to maintain Levodopa levels in the blood, providing greater relief from Parkinson's disease symptoms.

• Dosage and Administration:

  • The optimum daily dose must be determined by careful titration of levodopa in each patient.

  • Patients should be instructed to take only 1 tablet per dose administration.

  • The maximum recommended daily dose of entacapone is 2,000 mg.

  • Usually, this tablet is used in patients who are currently treated with corresponding doses of standard release levodopa/DDC inhibitor and entacapone.

  • Method of administration: Each tablet is to be taken orally either with or without food. The tablet may only be administered as a whole tablet.

• Common Side Effects: Dyskinesia, nausea, hyperkinesia, change in urine color, diarrhea, and stomach pain. Other side effects may include diarrhea, sometimes severe; colitis; hallucinations; other mental disturbances; orthostatic hypotension; rhabdomyolysis; and symptoms resembling neuroleptic malignant syndrome (a condition characterized by high fever, muscle stiffness, and confusion); fibrosis; skin cancer, etc.

• Important Notes:

  • It is unsafe to consume alcohol while taking Syncapone 50.

  • Syncapone 50 may be unsafe to use during pregnancy.

  • Syncapone 50 is probably unsafe to use during breastfeeding.

  • Syncapone 50 may cause dizziness or drowsiness, so caution is advised when driving or operating machinery.

  • Periodic evaluations of hepatic, hematopoietic, cardiovascular, and renal function are recommended during extended therapy.

• Contraindications:

  • Hypersensitivity.

  • Narrow-angle glaucoma.

  • Should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.

• Use in Special Populations

  • Children: Safety and effectiveness in pediatric patients have not been established.

  • Elderly: No dose adjustment is required for elderly patients.

  • Hepatic impaired patients: Should be administered cautiously to patients with mild to moderate hepatic impairment. Dose reduction may be needed.

  • Renally impaired patients: Should be administered cautiously to patients in severe renal impairment including those receiving dialysis therapy.

• Drug Interactions: Dopamine receptor antagonists (e.g., some antipsychotics and antiemetics), phenytoin, and papaverine may reduce the therapeutic effect of levodopa. Increased risk of postural hypotension when used concurrently with hypotensive drugs.

• Overdose Effects: The acute symptoms and signs of overdose include agitation, confusional state, coma, bradycardia, ventricular tachycardia, Cheyne-Stokes respiration, discolorations of skin, tongue and conjunctiva, and chromaturia. Hospitalization is advised, and general supportive measures should be employed with immediate gastric lavage and repeated doses of charcoal over time.

• Storage Conditions: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.