Indications

Terbex is indicated for the treatment of various fungal infections:

• Tablet (Oral):Onychomycosis (fungal infection of the toenail or fingernail) due to dermatophytes (Tinea Unguium).

• Granules (Oral):Tinea Capitis (scalp ringworm).

• Cream (Topical): Fungal infections of the skin caused by Trichophyton species (e.g., Tinea Corporis/Cruris/Pedis), cutaneous Candidiasis, and Pityriasis Versicolor.

• 1% Spray (Topical):Tinea infections of the skin and Pityriasis Versicolor.

Pharmacology

Terbinafine, an Allylamine antifungal, kills fungal cells by inhibiting the Squalene Epoxidase enzyme. This causes Squalene to accumulate, increasing the cell membrane's permeability, which leads to fungal cell death.

Dosage & Administration

Note: For oral treatment, the full clinical effect on nails is seen months after treatment ceases, as it relies on the growth of a healthy nail.

Contraindications & Warnings

• Contraindications: Hypersensitivity to terbinafine.

• Liver Risk (Tablets): Rare cases of fatal liver failure have been reported. Treatment must be stopped immediately if there is clinical or biochemical evidence of liver injury. Pretreatment serum transaminase ( and ) tests are advised. Terbex is not recommended for patients with chronic or active liver disease.

• Skin Reactions (Tablets): Serious skin reactions (e.g., Stevens-Johnson Syndrome) can occur. Discontinue treatment if a progressive skin rash develops.

• Topical: For external use only; avoid contact with eyes.

Side Effects

Common adverse events include GI symptoms (diarrhea, dyspepsia, abdominal pain), rashes, itching, and taste disturbances. Serious but rare side effects include hepatic injury and severe neutropenia.

Pregnancy & Lactation

Terbinafine tablets are not recommended to be initiated during pregnancy or for nursing mothers, as the drug is present in breast milk.

Therapeutic Class: Other Antifungal preparations, Topical Antifungal preparations.

Storage: Store below 30∘C, protected from light.