Traneta M 1000 

Presentation: Each tablet of Traneta M 1000 contains Linagliptin INN 2.5 mg and Metformin Hydrochloride BP 1000 mg. 

Indications: Traneta M is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both linagliptin and metformin is appropriate.

Dosage and Administration: The dosage of Traneta M should be individualized based on the patient's current regimen, effectiveness, and tolerability, not exceeding the maximum recommended daily dose of linagliptin 5 mg and metformin hydrochloride 2000 mg. It is generally taken twice daily with meals. Dose escalation should be gradual to reduce the gastrointestinal side effects associated with metformin.

• Recommended starting dose in patients not currently treated with metformin: Initiate treatment with one tablet of Traneta M (2.5 mg/500 mg) twice daily.
• Recommended starting dose in patients already treated with metformin: Start with one tablet of Traneta M containing 2.5 mg linagliptin and the current dose of metformin twice daily.
• Patients already treated with linagliptin and metformin as separate tablets may be switched to Traneta M containing the same doses of each component.
• Swallow tablets whole with water; do not crush or chew.

Side Effects: Common side effects may include diarrhea, nausea, vomiting, upset stomach, headache, and nasopharyngitis. Hypoglycemia may occur when Traneta M is used in combination with insulin or sulfonylureas.

Precautions: Traneta M is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis (including diabetic ketoacidosis), or known hypersensitivity to linagliptin or metformin. It is not recommended in patients with moderate renal impairment (eGFR 30-45 mL/min/1.73 m²) unless the benefit is considered to outweigh the risk, and renal function should be closely monitored. Caution is advised in patients with hepatic impairment or heart failure. Avoid excessive alcohol intake. Renal function should be assessed prior to initiation and periodically thereafter.

Storage: Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.