Tridopa 100

Presentation:

• Each tablet contains Levodopa BP 100 mg, Carbidopa BP 25 mg, and Entacapone BP 200 mg.  

   

Indications:

• Treatment of adult patients with Parkinson's disease and end-of-dose motor fluctuations not stabilized on levodopa/dopa decarboxylase(DDC) inhibitor treatment.  

Dosage and Administration:

• The optimum daily dose must be determined by careful titration of levodopa in each patient.  
• Patients should be instructed to take only 1 (one) tablet per dose administration.  
• The maximum recommended daily dose of entacapone is 2,000 mg. 
• Usually, this combination isused in patients currently treated with corresponding doses of standard release Levodopa or Dopa Decarboxylase (DDC) inhibitor and entacapone.  
• Tridopa 100 tablets should be swallowed whole with water, with or without food. Keep a consistent diet. A change in diet high in protein may delay levodopa absorption.  

Pharmacology: 

• This is a combination of levodopa, carbidopa, and entacapone for the treatment of Parkinson's disease.Levodopais converted to dopamine in the brain.Carbidopa inhibits the peripheral metabolism of levodopa, allowing more to reach the brain.Entacapone inhibits COMT, an enzyme that breaks down levodopa, resulting in more sustained levodopa levels.  

Side Effects: 

• Common side effects include dyskinesia, nausea, hyperkinesia, change in urine color, diarrhea, and stomach pain.  
• Other side effects may include diarrhea (sometimes severe), colitis, hallucinations, other mental disturbances, orthostatic hypotension, rhabdomyolysis, and symptoms resembling neuroleptic malignant syndrome.  

Precautions:

• May cause dizziness and symptomatic orthostatism. Exercise caution while driving or using machines.
• Periodic evaluations of hepatic, hematopoietic, cardiovascular, and renal function are recommended during extended therapy.  
• Use with caution in patients with cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disorders or with a history of peptic ulcer disease or upper gastrointestinal bleeding.
• Symptomatic postural hypotension may occur when levodopa is added to the treatment of patients already receiving antihypertensive drugs.  
• Iron salts may reduce the amount of levodopa available to the body.

Contraindications: 

• Narrow-angle glaucoma. 
• Phaeochromocytoma. 
• History of neuroleptic malignant syndrome (NMS) and/or non-traumatic rhabdomyolysis. 
• Severe hepatic impairment. 
• Concurrent use of or within 14 days of discontinuing non-selective MAOIs.  

Pregnancy and Lactation:

• The combination should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
• Women should not breast-feed during treatment.

Storage:

• Store in a cool and dry place, protected from light.
• Keep out of the reach of children.

Therapeutic Class:

• Anti-Parkinson Drugs.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.