Tryptin Plus

Presentation:Each film-coated tablet contains Amitriptyline Hydrochloride USP 12.5 mg and Chlordiazepoxide USP 5 mg.  

Indications:Tryptin Plus is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.Symptoms likely to respond in the first week of treatment include insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation, and anorexia.  

Dosage & Administration:Optimum dosage varies with the severity of the symptoms and the response of the individual patient. When a satisfactory response is obtained, the dosage should be reduced to the smallest amount needed to maintain remission. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient.An initial dosage of 3 or 4 tablets daily in divided doses is generally satisfactory.Follow the physician's instructions.

Side Effects:Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness, and lethargy, have been reported as side effects of treatment with Tryptin Plus.   The most frequently reported adverse reactions include drowsiness, dry mouth, constipation, blurred vision, dizziness, and bloating. Less commonly reported side effects include vivid dreams, impotence, tremor, confusion, and nasal congestion.  

Precautions:Use with caution in patients with a history of seizures. Close supervision is required when Tryptin Plus is given to hyperthyroid patients or those on thyroid medication.The usual precautions should be observed when treating patients with impaired renal or hepatic function.  Safe use during pregnancy and lactation has not been established.Exercise caution in elderly or debilitated patients, limiting the dosage to the smallest effective amount to preclude the development of ataxia, oversedation, confusion, or anticholinergic effects.  

Drug Interactions:Because of its Amitriptyline component, Tryptin Plus may block the antihypertensive action of guanethidine or compounds with a similar mechanism of action.It should not be given concomitantly with a monoamine oxidase inhibitor (MAOI).

Storage:Store below 30°C, protected from light and moisture.Keep out of reach of children.