Unigerd 20 

Presentation: Each film-coated tablet of Unigerd 20 contains Vonoprazan Fumarate INN equivalent to Vonoprazan 20 mg. Unigerd 20 is a product of NIPRO JMI Pharma Ltd. in Bangladesh and is usually available in blister packs.

Indications: Unigerd (Vonoprazan) is indicated for:

• Treatment of gastric ulcer.
• Treatment of duodenal ulcer.
• Treatment of reflux esophagitis (erosive esophagitis).
• Prevention of recurrence of gastric ulcer or duodenal ulcer during low-dose aspirin administration.  
• Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration.  
• Adjunctto Helicobacter pylorieradicationin the following conditions: gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer,or Helicobacter pylorigastritis.  

Dosage and Administration: Unigerd 20 tablets should be taken orally without regard to food or timing of food.

• Gastric ulcer: The usual adult dose is 20 mg once daily for up to 8 weeks.
• Duodenal ulcer: The usual adult dose is 20 mg once daily for up to 6 weeks.
• Reflux esophagitis: The usual adult dose is 20 mg once daily for up to 4 weeks. If healing is incomplete, treatment may be extended up to 8 weeks. For maintenance therapy of healed erosive esophagitis showing recurrence and recrudescence, the dose is 10 mg once daily, which may be increased up to 20 mg once daily if efficacy is inadequate.
• Prevention of recurrence of gastric or duodenal ulcer during NSAIDs administration: The usual adult dose is 10 mg once daily.  
• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration:The usual adult doseis 10 mg once daily.
• Helicobacter pylori eradication: The usual regimen for adults is Vonoprazan 20 mg, Amoxicillin 750 mg, and Clarithromycin 200 mg, all taken twice daily for 7 days. The dose of Clarithromycin may be increased up to 400 mg twice daily if clinically warranted. If this regimen is unsuccessful, an alternative three-drug regimen with Metronidazole may be used.

The dosage and duration of treatment should be determined by a physician based on the individual patient's condition.

Side Effects: The most common side effects reported with Unigerd (Vonoprazan) include:

• Diarrhoea
• Constipation
• Nausea
• Abdominal distension
• Increased liver enzymes (ALT, AST, gamma-glutamyl transferase)
• Rash

Other side effects may include drug hypersensitivity reactions (such as urticaria and anaphylactic shock), drug eruption, hepatotoxicity, and jaundice.

Precautions: Unigerd (Vonoprazan) is contraindicated in patients with hypersensitivity to Vonoprazan or any excipients in the product, and in patients receiving atazanavir sulphate, nelfinavir, or rilpivirine hydrochloride.

Caution should be exercised in pregnant women or women having the possibility of being pregnant, and it should be used only if the expected therapeutic benefit outweighs any possible risk. It is advisable to avoid the administration of Vonoprazan to nursing mothers; if indispensable, nursing should be discontinued.

Storage: Store below 30°C, in a cool and dry place, protected from light. Keep out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.