Valex CR 200

Presentation: Each controlled-release tablet contains Sodium Valproate BP 133.2 mg and Valproic Acid BP 58 mg (equivalent to Sodium Valproate 200 mg). Tablets are typically enteric-coated and supplied in blister packs or strips.

Indications: Valex CR is indicated for the treatment of all types of epilepsy, including partial seizures, absence seizures (petit mal), generalized tonic-clonic seizures (grand mal), myoclonic seizures, atonic seizures,¹and mixed seizures that include absence attacks. It is also indicated for the prophylaxis of febrile convulsions and post-traumatic epilepsy, as well as in the treatment of bipolar disorder (for the management of manic episodes) and the prophylaxis of migraine headaches.

Dosage and Administration: Valex CR tablets should be swallowed whole and should not be crushed or chewed. They are usually taken once or twice daily, preferably after food. Dosage is individualized and should be determined by the physician based on the patient's condition and response.

• Epilepsy (Adults): Initially 600 mg daily in 2 divided doses, increasing by 200 mg/day at 3-day intervals to a maximum of 2.5 g daily in divided doses until seizure control is achieved. Usual maintenance dose is 1-2 g daily (20-30 mg/kg daily).
• Epilepsy (Children over 20 kg):Initially 400 mg daily in divided doses, increased until control (usually in the range of 20-30 mg/kg²daily), with a maximum of 35 mg/kg daily.
• Epilepsy (Children up to 20 kg): Initially 20 mg/kg daily in divided doses, may be increased with plasma concentration monitoring.
• Febrile Convulsion:20-30 mg/kg/day in 3 divided doses. 
• Bipolar Disorder:Initially 600 mg daily (20-30 mg/kg/day) in 2-3 divided doses,adjust dosage in 3-5 days. Maintenance dosage is usually 1000-2000 mg daily.
• Prophylaxis of Migraine: Usually 400-600 mg daily, although some may require up to 1000 mg daily.

Follow the physician's instructions carefully.

Side Effects: Common side effects may include anorexia, nausea, vomiting, sedation, ataxia, and tremor. These gastrointestinal side effects may be reduced by using enteric-coated tablets. Other less frequent side effects include rash, hair loss, and increased appetite. Elevations of liver enzymes in plasma may occur, usually asymptomatically during the first few months of therapy.

Precautions: Valex CR should not be used in patients with known hypersensitivity to valproate or with liver disease. It is not recommended for use during pregnancy or in women of childbearing potential unless the clinical need outweighs the potential risk. Caution is advised in patients with renal impairment, systemic lupus erythematosus, and in breastfeeding mothers. Sudden withdrawal of therapy should be avoided. Valproate can interact with several other drugs, including phenobarbital, phenytoin, warfarin, and aspirin. Inform your physician about all medications you are currently taking.

Storage: Store below 30°C, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.